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Blood

Blood. Components of Blood. Whole blood RBCs WBCs Platelets: cell fragments that aid in clotting Plasma 90% water (allows materials to dissolve) Amino acids, glucose, hormones, vitamins, salts, waste Concentrations allows diffusion in/out of blood stream. Red Blood Cells.

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Blood

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  1. Blood

  2. Components of Blood • Whole blood • RBCs • WBCs • Platelets: cell fragments that aid in clotting • Plasma • 90% water (allows materials to dissolve) • Amino acids, glucose, hormones, vitamins, salts, waste • Concentrations allows diffusion in/out of blood stream

  3. Red Blood Cells • Job: Transport O2 to cells • Produced from stem cells in bone marrow • O2 binds to hemoglobin proteins • Dead cells filtered by liver & spleen

  4. Sickle Cell Normal

  5. White Blood Cells • Remove foreign invaders & dead cells • Able to move through body tissue

  6. Platelets • Form clots when bleeding • Proteins form a web to trap cells & platelets

  7. ABO Blood Groups • Proteins on blood cells determine blood type • Antigen (markers) • proteins on cell’s surface that identify cells as foreign or natural • Antibodies: • proteins from B cells to attack invaders • Float freely in plasma

  8. Group A blood • A antigens on the surface of your RBCs • B antibodies in your blood plasma

  9. Group B blood • B antigens on the surface of your RBCs • A antibodies in your blood plasma

  10. Group AB blood • Both A and B antigens on the surface of your RBCs • Neither A or B antibodies in your blood plasma

  11. Group O blood • Neither A or B antigens on the surface of your RBCs • Both A and B antibodies in your blood plasma

  12. If you have type A blood, can you receive: Type B blood from a donor? Type AB blood from a donor? Type O blood from a donor?

  13. If you have type B blood, can you receive: Type A blood from a donor? Type AB blood from a donor? Type O blood from a donor?

  14. If you have type AB blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type O blood from a donor?

  15. If you have type O blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type AB blood from a donor?

  16. Rh Factors • If Rh+ • Cells contain the Rh antigen • Can receive Rh+ or Rh- blood • If Rh- • Cells lack the Rh antigen • Plasma contains Rh antibody • Only receive Rh- blood

  17. Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?

  18. Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

  19. Francis has B+ blood type because of the B and Rh antigens. If he is given B+ blood in a transfusion… Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive B+ blood? Yes. Vein A antibody A antibody A antibody

  20. Francis has B+ blood type because of the B and Rh antigens. If he is given B- blood in a transfusion… Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive B- blood? Yes. Vein A antibody A antibody A antibody

  21. Francis has B+ blood type because of the B and Rh antigens. If he is given A+ blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive A+ blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  22. Francis has B+ blood type because of the B and Rh antigens. If he is given A- blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive A- blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  23. Francis has B+ blood type because of the B and Rh antigens. If he is given AB+ blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive AB+ blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  24. Francis has B+ blood type because of the B and Rh antigens. If he is given AB- blood in a transfusion… Will his antibodies attack this blood? Yes. His A antibodies will attack the A antigens. Can he receive AB- blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  25. Francis has B+ blood type because of the B and Rh antigens. If he is given O+ blood in a transfusion… Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O+ blood? Yes. Vein A antibody A antibody A antibody

  26. Francis has B+ blood type because of the B and Rh antigens. If he is given O- blood in a transfusion… Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O- blood? Yes. Vein A antibody A antibody A antibody

  27. Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?

  28. Blood type A- Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

  29. Sebastian has A- blood type because of the A antigen. If he is given A- blood in a transfusion… Will his antibodies attack this blood? No. His B and Rh antibodies only attack B and Rh antigens. Can he receive A- blood? Yes. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  30. Sebastian has A- blood type because of the A antigen. If he is given A+ blood in a transfusion… Will his antibodies attack this blood? Yes. His Rh antibodies will attack the donated Rh antigens. Can he receive A+ blood? No. Agglutination: clumping of the blood Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  31. Sebastian has A- blood type because of the A antigen. If he is given B- blood in a transfusion… Will his antibodies attack this blood? Yes. His B antibodies will attack the donated B antigens. Can he receive B- blood? No. Agglutination: clumping of the blood Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  32. Sebastian has A- blood type because of the A antigen. If he is given B+ blood in a transfusion… Will his antibodies attack this blood? Yes. Both his B and Rh antibodies will attack the donated B an Rh antigens. Can he receive B+ blood? No. Agglutination: clumping of the blood Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  33. Sebastian has A- blood type because of the A antigen. If he is given AB- blood in a transfusion… Will his antibodies attack this blood? Yes. His B antibodies will attack the donated B antigens. Can he receive AB- blood? No. Agglutination: clumping of the blood Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  34. Sebastian has A- blood type because of the A antigen. If he is given AB+ blood in a transfusion… Will his antibodies attack this blood? Yes. Both his B and Rh antibodies will attack the donated B and Rh antigens. Can he receive AB+ blood? No. Agglutination: clumping of the blood Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  35. Sebastian has A- blood type because of the A antigen. If he is given O+ blood in a transfusion… Will his antibodies attack this blood? Yes. His Rh antibodies will attack the donated Rh antigens. Can he receive O+ blood? No. Agglutination: clumping of the blood Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  36. Sebastian has A- blood type because of the A antigen. If he is given O- blood in a transfusion… Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O- blood? Yes. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  37. Blood type AB+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  38. Blood type O+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  39. Blood type AB- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  40. Blood type B+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  41. Blood type O- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  42. 1) Can this work? • Acceptor O- • Donor • AB- No! The acceptor has A & B antibodies. Their antibodies would attack the A & B antigens of the donated blood.

  43. 2) Can this work? • Acceptor A+ • Donor • A- Yes! The acceptor only has Rh antibodies. Since the donated blood has no Rh antigens, this is safe.

  44. 3) Can this work? • Acceptor AB- • Donor • B- Yes! The acceptor has the Rh antibodies. There are no Rh antigens on the donated blood.

  45. Kobe Kuiz • What are the components found inside blood? • What are the ingredients of plasma? • What is the purpose/function of RBCs? • Which part of blood stop bleeding when cut? • What do antibodies bind with? • If a person has type AB-, which antigens do they possess? Which antibodies? • If a person has type O+, which antigens do they possess? Which antibodies? • If a person is type A-, list all the blood types this person can receive in a transfusion. • If a person is type O-, list all the blood types this person can receive in a transfusion.

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