Blood

1. Blood Anatomy Chapter 12

2. 1. Formed Elements • erythrocytes- erythro- red cyte- cell ferry oxygen to all cells in body anucleated cells contain hemoglobin- iron containing protein which transports O2 biconcave disks- creates large surface area for carrying oxygen

4. make up 45% of total bld- hematocrit • normally 5 million cells/mm3 • each rbc contains 250 million hemoglobin molecules capable of binding 4 molecules of O2 • normal bld contains 12-18g/100mL

5. anemia- decrease in O2-carrying ability resulting from • lower # of rbs • abnormal/defi-cient hemoglobin content

6. sickle-cell anemia- genetic disorder • occurs most often in blacks

8. Leukocytes Info Sheet • State the main fxn of leukocytes. • Discuss the # of different types of wbc, name them, and list the 4 ways they are distinguished. • How many wbc are in a normal adult’s blood? • Name 2 ways in which wbc protect against infection. • Give examples of how doctors can use the wbc counts to indicate types of infections.

9. 6. Distinguish among the leukocytes that are granular and those that are agranular. (name them) 7. What is the difference between agranulocytes and granulocytes? 8. Discuss a unique property of leukocytes that enables them to get to a point of infection in the body. 9. Many leukocytes are phagocytes. What does this mean?

10. B. leukocytes- white blood cells leukos- white crucial to body’s defense against disease 4 000 to 11 000 wbc/mm3 make up 1% total bld volume form a “movable army” against invaders

11. able to slip in & out of bld vessels- diapedesis use circulatory system as means of transportation to respond to inflammatory or immune responses

13. move by ameboid motion thru tissue until get to damaged or infected area • have infection, wbc counts go up • if 11 000 cells/mm3 have leukocytosis • mononucleosis & leukemia- high # wbc

14. 2 major groups of wbc • granulocytes- contain visible granules in cytoplasm have lobed nuclei develop from red bone marrow

15. neutrophils- most active leukocytes most numerous- 3 000 to 7 000 phagocytotic- ingest bacteria and dead matter; die soon after release bacteria destroying subst 2 – 5 lobed nucleus pale purple staining incr during bacterial infection & acute infections

16. high #s- appendicitis, rheumatic fever; fewer- flu, rubella, hepatitis

17. b. eosinsophils- 100-400 figure 8 nucleus or bilobed deep red granules in cytoplasm; blue red nucleus weakly phagocytic numbers incr during allergy attacks kills parasites (worms)

18. high #s- asthma, parasitic diseases, hay fever

19. c. basophils- 20-50/mm3 deep blue granules; u or s shaped nucleus discharge histamines (which incrbld flow to site of inflammation) secrete heparin to prevent clotting of bld

20. high #s- chicken pox, hemolytic anemia

21. 2. agranulocytes- lack visible granules nuclei spherical, oval, or kidney shaped Some differentiate in lymphatic organs after red bone marrow

22. Lymphocytes d. b-lymphocytes- produce antibodies 1500-3000 (combined) pale blue cytoplasm; dark purple nucleus #s will drop significantly due to AIDS

23. e. t-lymphocytes- slightly larger than rbc large round nucleus w/ thin rim of cytoplasm important in immunity graft rejection and fighting tumors and viruses may live for years 2nd most numerous group of wbc (combined) when #s incr could indicate mono or chronic infection

25. f. monocytes- phagocyticwbc • 100-500 • largest blood cell; capable of digesting large cells • clean up cells after infection • gray-blue cytoplasm; dark blue-purple staining nucleus • contains many lysosomes

26. # increase during chronic infections • if # incr dramatically could indicate malaria, endocarditis, typhoid fever, Rocky Mtn spotted fever

27. 2. Thrombocytes (platelets) • 250 000 to 500 000/mm3 • irregularly shaped cell fragments • circulate about 10 days • capable of ameboid motion • no nucleus; cytoplasm stains dark purple

28. imp role in bld clotting • help to close breaks in damaged bld vessels and to initiate formation of bld clots • hematostasis

31. 3. Plasma • liquid part of blood • 92% water • 55 % of whole blood • straw-colored, salty taste, sticky • contains plasma proteins made by liver; contributes to osmotic pressure of bld

33. helps regulate fluid and electrolyte balance • maintain favorable blood pH • helps distribute body heat

35. Hematopoiesis • aka blood cell formation • occurs in red bone marrow of flat bones • all formed elements of bld arise from hemocytoblast (stem cell) • hemocytoblast forms 2 types of cells which will then differentiate into the different formed elements thru series of steps

37. takes about 5-7 days to make a mature rbc • rbc production controlled by a certain hormone released by kidney

38. Hemostasis • stoppage of bld flow • have damaged bld vessel 3 phases that will occur: 1. vascular spasms 2. platelet plug formation 3. blood clot formation

39. platelets begin to cling to damaged parts serotonin is released causing bld vessels to go into spasms which narrows vessels platelets release thromboplastin which triggers clotting

40. bld clot formation- aka coagulation thromboplastin is converted to thrombin, which joins fibrinogen which makes a net to trap rbc (very sticky) usu occurs in 2-6 minutes

42. 2 major disorders w/ clotting: • undesirable clotting- thrombus- clot develops in leg (usu) and persists embolus- when thrombus flows thru vessels if lodged, can kill

43. 2. hemophilia- hereditary bleeding disorder that results from the lack of protein factors that lead to clotting aka “free-bleeders”

44. minor tissue trauma can lead to prolonged bleeding and even death • thrombocytopenia- insufficient # of platelets

45. Leukemia • cancer of the white blood cells • too many wbc are being produced, not enough rbc and platelets • fatigue, frequent illness, anemia, slow clotting (bruising), painfully weak bones • treatments: • bone marrow transplants, stem cell transplants, meds

46. Blood Typing • 4 blood types: A, B, O, AB • all body cells produce “markers” on the cell membranes that identify them as unique & you • these are antigens • for cells that aren’t yours, your body recognizes the antigens as FOREIGN

47. antigens of foreign cells stimulate immune system to release antibodies to fight against them • we all have “recognizer antibodies” in our bld stream that recognizes foreign antigens

48. these antibodies will bind onto the foreign substance (rbc, for ex) causing agglutination or clumping • mismatched blood may cause death

49. symptoms: anxiety, breathing difficulty, flushing, headache, severe pain in neck, chest, lumbar region, rbc burst- leading to jaundice, kidney failure

50. Rh factor- • discovered on rhesus monkeys 1st • most Americans are Rh+ • Have Rh antigen on rbc • Rh- do not have antigen on rbc