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Inflammation and nose

Inflammation and nose. Exposure group – Bitumen workers. Reference group – outdoor construction workers. Characteristics of the study population. Low exposure. Low exposure. High exposure. High exposure. References. References. Exposed (total). Exposed (total). ?10 mg/m.  10 mg/m.

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Inflammation and nose

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  1. Inflammation and nose

  2. Exposure group – Bitumen workers

  3. Reference group – outdoor construction workers

  4. Characteristics of the study population Low exposure Low exposure High exposure High exposure References References Exposed (total) Exposed (total) ?10 mg/m 10 mg/m >10 mg/m 10 mg/m 3 3 3 3 Attribute Attribute n=55 n=55 n=202 n=202 n=172 n=172 n=30 n=30 Exposure to fumes Exposure to fumes of and aerosols of 3.7 (0.1 3.7 (0.1 - - 41.7) 41.7) 3.0 (0.1 3.0 (0.1 - - 9.8) 9.8) 16.7 16.7 (10.2 (10.2 - - 41.7) 41.7) 3 3 bitumen (mg/m bitumen (mg/m ) ) - ? (median; range) (median; range) Age (years) Age (years) 37 (19 37 (19 - - 61) 61) 40 (17 40 (17 - - 63) 63) 40 (18 40 (18 - - 63) 63) 40.5 (17 40.5 (17 - - 52) 52) (median; range) (median; range) Current smoking Current smoking 23 ( 23 ( 41.8 41.8 %) %) 132 ( 132 ( 65.7 65.7 %) %) 113 (65.7%) 113 (65.7%) 20 (66.7%) 20 (66.7%) n (%) n (%) German nationality German nationality 48 ( 48 ( 87.3 87.3 %) %) 136 ( 136 ( 67.7 67.7 %) %) 121 (70.8%) 121 (70.8%) 15 (50.0%) 15 (50.0%) n (%) n (%) Duration of work in Duration of work in the current the current company (years) company (years) 6.5 (3 6.5 (3 - - 10) 10) 8 (3 8 (3 - - 14 14 ) ) 8 (3 8 (3 - - 14) 14) 6.5 (2 6.5 (2 - - 16) 16) (median; (median; interquartile range) interquartile range)

  5. Collection of nasal lavage fluids (NALF) Analysis: cellular and humoral parameters (e.g. IL-8, IL-1b, TNF-a, IL-6, NO, albumin)

  6. Neutrophils in NALF [%] – pre-/post-shift-comparison in the three exposure groups 60 55 50 45 p=0.023 p=0.010 40 Neutrophils in NALF [%] 35 p=0.020 p=0.0002 30 25 20 15 pre-shift post-shift reference group low exposure group high exposure group

  7. IL-8-determination in NALF [%] – pre-/post-shift-comparison in the three exposure groups 350 300 250 200 n.s. IL-8-concentration in NALF [pg/ml] n.s. 150 100 50 0 pre-shift post-shift reference group low exposure group high exposure group

  8. Conclusion NALF • Small increase of neutrophils after high airborne bitumen exposure during shift in nasal lavage • Although no direct comparison was made, irritative effects can possibly be differentiated from allergic effects

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