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Triosephosphate isomerase. Adenosine deaminase. Cytidine deaminase. Ketosteroid isomerase. Chorismate mutase. Cyclophylin. Carbonic Anhydrase. OMP Decarboxylase. Staph. nuclease. Catalytic Perfection. 10 10. 10 8 -10 9 M -1 s -1. k cat /K m. (M -1 s -1 ). 10 5. 1. t 1/2 1 min.

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10 -15

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  1. Triosephosphate isomerase Adenosine deaminase Cytidine deaminase Ketosteroid isomerase Chorismate mutase Cyclophylin Carbonic Anhydrase OMP Decarboxylase Staph. nuclease Catalytic Perfection 1010 108-109 M-1s-1 kcat/Km (M-1s-1) 105 1 t1/21min. 10-5 knon (s-1) 10-10 OMP Decarboxylase : The best enzyme known t1/2106 years 10-15 Rate constants for nonenzymatic (knon) reactions (bottom, blue squares) in units of s-1 and for enzymatic (kcat/Km) reactions (top, red circles) in units of M-1s-1 in neutral solution at 25 deg. C. Enzyme proficiency ((kcat/Km)/knon) is indicated by the length of the vertical bars. From Science, vol 267, 90-93 (1995)

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