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A European project on patient-specific modeling and simulation of FUS in moving organs

Stefan Braunewell Fraunhofer MEVIS - Institute for Medical Image Computing, Bremen Jenny Dankelman , Thomas Langø, Jürgen Jenne , Michael Müller, Yoav Levy, Mario Bezzi, Christine Tanner, Calin Tiu, Daniel Outmazguine, Matthias Günther, Andreas Melzer, Tobias Preusser.

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A European project on patient-specific modeling and simulation of FUS in moving organs

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  1. Stefan Braunewell Fraunhofer MEVIS - Institute for Medical Image Computing, Bremen Jenny Dankelman, Thomas Langø, Jürgen Jenne, Michael Müller, Yoav Levy, Mario Bezzi, Christine Tanner, Calin Tiu, Daniel Outmazguine, Matthias Günther, Andreas Melzer, Tobias Preusser A European project on patient-specific modeling and simulation of FUS in moving organs

  2. Focused Ultrasound in theLiver Focused Ultrasound • Reflection, refraction, absorption, cavitation • Heat transfer, tissue reaction • Cooling by blood flow and perfusion • Breathing motion • Occlusion by ribcage Computer simulationrequiredforreliableoutcomeprediction

  3. Goal of FUSIMO Develop, implement and validate a multi-level model for FUS simulation in moving abdominal organs FUSIMO softwaresystemaids in: • Assessing feasibility • Optimizing outcome • Detecting risks • Monitoring progress, tracking deviations • Training

  4. Prediction of Respiratory Motion Image of patient Pre-therapy Intra-operative ultrasound On-line Generic 4D respiratory motion model Off-line Prediction On-line 4DMRI to observe organ motion Quantify organ motion for population

  5. US andtemperaturesimulation Rib oC Incorporationofmotion [mm] Target XD [mm] [mm] oC Heterogeneousmedia Deactivationofelements [mm]

  6. Parameter identification MR thermometry of sonication in agar gel Simulated sonication after recalibration Temperature across lesion Temperature along lesion Estimate constant thermal conductivity during cooling period from MR thermometry in Agar gel. Estimate constant thermal conductivity during cooling period from MR thermometry in Agar gel.

  7. Functional Modeling • Cooling effects due to vessels • Prediction of supply and drainage areas for blood flow • Prediction and monitoring of tissue damage

  8. Simulation results Planning Image Pressure Temperature Damage Risk

  9. Integrated Software System • Segmentation • Preview of presumed motion • Interactive Planning • Exploration of Results • Progress monitoring • Assessment, training

  10. Multi-level validation • Volunteers • Motion tracking • Motion model • MR imaging protocols • Phantoms • US, temperaturesimulation • Steered sonications

  11. System validation • Validateandoptimizeworkflow • PositioningusingInnomotion Robot Arm • Thiel cadavers • Motion model • Perfusion • Steered sonications Renal arteryperfusion in cadaver

  12. FUSIMO Take Home Message Integrated software systemfor FUS in movingorgans • Assessing feasibility • Optimizing outcome • Detecting risks • Monitoring progress, tracking deviations • Training

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