1 / 9

AP2/EREBP Transcription Factor Family

AP2/EREBP Transcription Factor Family. Garen and Joanna. Transcription Factors. Transcription Factors (TF) are proteins that regulate the transcription of genes Three general categories of TFs Bind to RNA Polymerase Bind to another TF Bind to specific DNA sequences

ponce
Download Presentation

AP2/EREBP Transcription Factor Family

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. AP2/EREBP Transcription Factor Family Garen and Joanna

  2. Transcription Factors • Transcription Factors (TF) are proteins that regulate the transcription of genes • Three general categories of TFs • Bind to RNA Polymerase • Bind to another TF • Bind to specific DNA sequences • Most bind upstream of the target gene in the promoter sequence

  3. What is AP2? • AP2 derives name from APETALA2 protein • Domain sequence of 70 amino acids • Unique to Plants • Contain either 1 or 2 AP2 Domains • EREBP and AP2 subfamilies • Present during many stages of plant development in all organs • Our focus is seed development

  4. 3 Types of AP2 Proteins • Three classes of single AP2 repeat proteins • Ethylene Response Elements Binding Proteins (EREBPs) • Dehydration Response Elements (DREs) • RAV1 and RAV2

  5. Sub-families of AP2

  6. What is its role in plants? • Are involved in various aspects of plant growth and development • Flower Development • Hormone signal transduction • Cellular Differentiation • Responds to biotic and abiotic stresses • Drought (DREs) • Low Temperature • Pathogens

  7. More specifically… • Certain AP2 genes control seed mass and seed size in Arabidopsis. • May negatively affect gibberellin activity in regulating cell size and number during seed development • Large seed size correlates with deformed flowers

  8. Mechanisms Wildtype Seed • Seed size affected two different ways when AP2-10 is non-functional • Seed cavity size enlarged • This allows for extended growth of cotyledons • Prolonged mitotic activity after torpedo stage leads results in extended growth of embryo Wildtype Seed Coat Mutant Seed Mutant Seed Coat

  9. Conclusion • AP2 transcription factors are crucial to many plant processes • Its effects on seed development may have significant repercussions in other organs, as exemplified by deformed flowers • Masking? • There’s still much we don’t know, but the research continues

More Related