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GENETIC MARKERS IN LYMPHOMA a practical overview

B and T cell monoclonalities Rearrangement of immunoglobin and TCR genes may help to establish the malignant nature of a lymphoproliferative lesion Identification of non-random chromosomal abnormalitiest(14;18) or t(11;14) translocations in FL and MCL respectively allow lymphoma subt

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GENETIC MARKERS IN LYMPHOMA a practical overview

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    1. GENETIC MARKERS IN LYMPHOMA a practical overview P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute

    2. B and T cell monoclonalities Rearrangement of immunoglobin and TCR genes may help to establish the malignant nature of a lymphoproliferative lesion Identification of non-random chromosomal abnormalities t(14;18) or t(11;14) translocations in FL and MCL respectively allow lymphoma subtype classification

    3. B and T cell monoclonality what does that mean?

    4. During early lymphoid development, the genes encoding antigen receptor undergo rearrangement example of the Ig heavy chain locus (IgH)

    7. B and T cell monoclonalities - PCR Illustration on ethidium-bromide-stained gel

    8. B and T cell monoclonalities - PCR Illustration on Genescan

    9. PCR

    12. PCR - Pitfalls

    13. Rules to known (1)

    14. Rules to known (2)

    16. Chromosomal abnormalities

    19. Recurrent genetic abnormalities in lymphoma

    20. Follicular lymphoma (1)

    21. Follicular lymphoma (2)

    22. Follicular lymphoma (3) what to know

    23. Follicular lymphoma (5) what to know

    24. Follicular lymphoma (4) what to know

    25. PCR Bcl2-JH in follicular lymphoma Illustration

    26. Follicular lymphoma (5) what to know

    27. Mantle Cell lymphoma

    28. Mantle cell lymphoma (2)

    29. Mantle cell lymphoma (3) what to know

    30. Mantle cell lymphoma (3) what to know

    31. Marginal cell lymphoma (1)

    32. Marginal cell lymphoma (2 ) MALT type

    33. t(11;18)(p21;q21) / API2-MALT in gastric MALT lymphoma

    34. splenic Marginal cell lymphoma (3)

    35. Diffuse Large B cell lymphoma (1)

    36. Diffuse Large B cell lymphoma (2) Illustration

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