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Electroconvulsive Therapy. Jerome Greenfield M.D. Historical Background. Hippocrates 400 B.C. Melancholic “black bile” Paracelsus 1520 Psychiatric illness not demonic but natural diseases Kraeplin Illnesses divided into two major groups. Etiologies of Depression.
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Electroconvulsive Therapy Jerome Greenfield M.D.
Historical Background • Hippocrates 400 B.C. Melancholic “black bile” • Paracelsus 1520 Psychiatric illness not demonic but natural diseases • Kraeplin Illnesses divided into two major groups
Etiologies of Depression • Bioamine Hypothesis Neurotransmitters • Freud Loss of the love object • Genetic Factors • Life’s Stressors • Learned Helplessness • Cognitive Theories • Organic Cause drugs, medications, illnesses, sleep abnormalities
Epidemiology • 20% lifetime expectancy • 2:1 female to male ratio • 50% have onset by age 30 • More common in single/divorced • No correlation between social classes or race • 10% complete suicide 66% contemplate
Treatment Options • Medications • ECT • Transcranial Magnetic Therapy • Vagal Nerve Stimulator • Various Psychotherapies • Psychoanalysis
ECT History • Can a seizure be protective? • Meduva 1930’s camphor • Cerletti and Bini electrical charge • 75,000 treatments per year • Twice as effective as medication • Mortality .01% per course same as any anesthesia induction
ECT INDICATIONS • Major Depression 90% effective • Mania 80% effective • Acute Schizophrenic Psychosis 50% effective • Neuroleptic Malignant Syndrome • Advanced Parkinson’s • Intractable Epilepsy • Catatonia
Contraindications • No absolute contraindications • High risk with: Space occupying lesion Recent myocardial infarction Brain aneurysm
ECT Procedure • Confirm Diagnosis • Medical and Psychiatric Exam • EKG • Lab tests • Head CT/Spine films if indicated • Consent forms • Anesthesia evaluation • Risks, benefits, alternatives
Primary Choice • Urgent need for rapid response • Patient history • Patient preference • Elderly • Psychotic Depressions • Catatonic States
Adverse Effects • General Anesthesia • Complicated seizure • Medication Interactions • Cognitive Changes • Cardiovascular Problems
Risk Reduction • Oxygenation • Reduce medications • Pre treatment with Robinul • Use of Beta Blockers • Check electrolytes • BP and EEG monitoring • NPO after midnight, clean scalp, usual BP meds with sip of water • Atropine if necessary
Anesthetic Agents • Diprovan Non barbituate short acting • Brevital barbituate yet less effect on seizure • Succinylcholine • Beta Blockers • Versed
Misc Items • Sine wave vs. brief pulse • Seizure threshold meds, age • Number of treatments • Mostly done on out patient basis • Maintenance ECT • Lengthen Seizure Caffeine, Hyperventilation, Wellbutrin • Abort Seizure Valium
Amnesia • Retrograde and Anterograde • Few weeks to month in duration • Less with non dominant unilateral treatment • Discontinue Lithium • Occurs in patients with severe Depression who do not have ECT • BDNF theory • ECT does not injure the brain
Complications • Headache, muscle soreness • Jaw pain, oral injury • Spinal problems • Nausea • Confusion • Cardiovascular Problems • Death 1:10,000
Special Conditions • Pregnancy Meds are non-teratogenic • Cardiovascular Illnesses K, Pacemaker • Diabetes • Asthma • Epilepsy
How does it work? • Not sure!!! • Massive release of neurotransmitter? • Alteration in seizure threshold? • Akin to re-boot of a computer?
Consent • Description of the procedure • Why recommended • Alternative treatment • Benefits may be transient • Behavioral restrictions • Voluntary treatment • Available to answer questions • Implies consent for emergency treatment • Risks major and minor