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Goodpasture’s Syndrome

Goodpasture’s Syndrome. By: Morgan Collins & Heather Ratcliff. What is Goodpasture’s Syndrome?. Goodpasture's Syndrome is a rare autoimmune disease that affects both the kidneys and the lungs. The cause is unknown but researchers believe it may have something to do with genetics. .

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Goodpasture’s Syndrome

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  1. Goodpasture’s Syndrome By: Morgan Collins & Heather Ratcliff

  2. What is Goodpasture’s Syndrome? • Goodpasture's Syndrome is a rare autoimmune disease that affects both the kidneys and the lungs. • The cause is unknown but researchers believe it may have something to do with genetics. Bad Kidneys

  3. How is Goodpasture’s Syndrome an autoimmune disease? • The disease occurs when the body's immune system mistakenly produces antibodies against collagen in the lungs and kidneys. • Collagen is a protein that helps form connective tissue. Stained glomerulus from a patient with anti-GBM glomerulonephritis showing a large cellular crescent that contains an unusually prominent component of neutrophils.

  4. Symptoms: • The first signs of Goodpasture’s syndrome may include: -Fatigue -Nausea and vomiting -Difficulty breathing -Pale skin • When Goodpasture’s syndrome affects the lungs: - shortness of breath -persistent cough, sometimes with blood. • When Goodpasture’s syndrome affects the kidneys, symptoms may include: -Blood in the urine -Foamy urine -Swelling in the legs -High blood pressure -Burning or difficulty when urinating -Back pain below the ribs -Swelling of the hands and feet

  5. Treatments: • Treatment usually includes oral immunosuppressive drugs. These drugs decrease the immune system's production of Goodpasture syndrome antibodies. • Intravenous corticosteroids may be needed to control bleeding in the lungs. • Treatment of Goodpasture syndrome also usually includes a procedure called plasmapheresis. This helps remove harmful antibodies from the blood.

  6. Other important information about Goodpasture’s Syndrome… • Diagnostic tests: -Urinalysis -Blood test -Chest X-ray -Biopsy • Goodpasture’s syndrome usually affects young men between 20-30 and older than 60. • It more often occurs among whites than among people of other races and ethnicities. • It is almost always fatal if it is not quickly diagnosed and treated.

  7. Work cited: • Jennette, Charles, and Nickeleit Volker. <http://www.kidneypathology.com.ar/13.htm>. • National Kidney Foundation, . N.p.. Web. 1 May 2013. <http://www.kidney.org/atoz/content/goodpasture.cfm>. • Patel, P.. N.p.. Web. 1 May 2013. <http://www.nlm.nih.gov/medlineplus/ency/article/000142.htm>. • Urinalysis . N.d. Photograph. PHPKB Knowledge Base SoftwareWeb. 1 May 2013. <http://www.knowledgebase-script.com/demo/article-331.html>. • WebMD, . N.p.. Web. 1 May 2013. <http://www.webmd.com/a-to-z-guides/goodpasture-syndrome>. • . N.p.. Web. 1 May 2013. <http://kidney.niddk.nih.gov/kudiseases/pubs/goodpasture/>.

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