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Transfer-messenger RNA

Transfer-messenger RNA . Macromolecules II May 4, 2009 Jane Yu. Discovery of tmRNA a small, stable RNA. Jain, et al. 1982. Ray and Apirion, 1979. Where is tmRNA found?. All sequenced eubacteria Some rare mitochondrial and plastidial genomes in simple eukaryotes such as diatoms.

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Transfer-messenger RNA

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  1. Transfer-messenger RNA Macromolecules IIMay 4, 2009 Jane Yu

  2. Discovery of tmRNAa small, stable RNA Jain, et al. 1982 Ray and Apirion, 1979

  3. Where is tmRNA found? • All sequenced eubacteria • Some rare mitochondrial and plastidial genomes in simple eukaryotes such as diatoms. • Some phage genomes • No nuclear genomes

  4. What is tmRNA?mRNA-like and tRNA-like properties

  5. Structure of tmRNA

  6. Ribosomal RNA is normally recycled post-translation

  7. tmRNA “rescues” ribosomes stalled during translation of mRNA lacking stop codons. A ribosome stuck with nonstop RNA

  8. tmRNA “rescues” ribosomes stalled during translation of mRNA lacking stop codons. A sad ribosome stuck with nonstop RNA

  9. tmRNA also:1) mediates degradation of the aberrant mRNA 2) adds a degradation tag to the aberrant protein for directed proteolysis Functions of tmRNA

  10. The tmRNA/SmpB complex

  11. Trans-translation

  12. Role in human disease Vital for normal growth in: Mycobacterium pneumoniae Neisseria gonorrhaeae Vital for pathogenesis in: Salmonella typhimurium (MP survival) Yersinia pseudotuberculosis (T3SS)

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