1 / 10

Microprosthetic Implant for the Treatment of Erectile Dysfunction

Microprosthetic Implant for the Treatment of Erectile Dysfunction. Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher. Thesis. A microprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction. Minimally invasive

raina
Download Presentation

Microprosthetic Implant for the Treatment of Erectile Dysfunction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Microprosthetic Implant for the Treatment of Erectile Dysfunction Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher

  2. Thesis • Amicroprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction. • Minimally invasive • Patient compliance • Targeted drug release and control

  3. Erectile Dysfunction Background • Erectile Dysfunction (ED) • Prevalence in men 40-70 = 52%1 • Current treatment options • Prescription oral pills • Injection therapy • Penile prosthetics • Drug therapy market size • $3.1 billion in 2005 • Estimated growth of 6.5% annually through 20102

  4. Pathophysiology • Physiology of erection • Erectile tissue – cavernous smooth muscles • Low blood flow in flaccid state • Stimulation causes arterioles to dilate3 • Neurophysiologoy • Cavernous nerves – neurovascular control of erection/detumescence • Dorsal nerve – sensory function • Pathology of ED • Psychogenic • Neurogenic • Estimated at 10-19% • Iatrogenic • Arteriogenic • Combination

  5. Problem and Solution • Current solutions • Oral prescription drugs • Injection therapy • Mechanical prosthetics • Proposed solution • Drug delivery implant • Triggered by neural signals of dorsal nerve • Microcontroller interprets signal • Microinjector drug release • Microcontroller regulates reactivation

  6. Design Parameters • Dorsal nerve input interface • Drug reservoir, microprocessor, power supply, microinjector • Refillable reservoir • Power saving sleep mode • Candidates for drug release • Papaverine • Prostaglandin E1 • Affects reservoir size and flow specifications • Surgical Technique and Implantation • Site – Anterior face of pubic bone • Proximity to anatomical targets • Minimally invasive

  7. System Flow Chart

  8. Microprocessor Flow Chart

  9. Timeline of Future Work • Week ending 2/6/10 – Finalize list of components needed for proof of concept, consult with Dr. Doug Milam on device parameters • Week ending 2/13/10 – Order/fabricate proof of concept components • Week ending 2/20/10 – Contact pharmacologist and companies involved with related technologies • Week ending 2/27/10 – Assemble proof of concept device, change specifications with Dr. Doug Milam’s recommendations • Week ending 3/6/10 – Finalize specifications and component list for scaled up prototype device, order/fabricate components • Week ending 3/20/10 – Setup testing scenarios for prototype device • Week ending 3/27/10 – Begin assembly of prototype device • Week ending 4/3/10 – Complete prototype device assembly, begin device testing • Week ending 4/10/10 – Complete device testing, calculate specifications for to-scale device

  10. References • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. Urology 1994; 151: 54-61. • Elder, Melissa. Men’s Health: The Worldwide Market for Current and Emerging Drug Therapies, 2nd ed. Kalorma Information. May 2006. • Robert C. Dean, MD and Tom F. Lue, MD. Physiology of penile erection and pathophysiology of erectile dysfunction. UrolClin North Am. 2005 November; 32(4): 379-v. • “Codman 3000.” Codman Pumps. 15 Oct. 2009. Web. <http://www.codman.com/DePuy/products/Products/neuromodulation/pump/index.html>. • Sacral Plexus of the Right Side. Gray’s Anatomy.

More Related