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Department of Genetics, Microbiology and Toxicology (GMT)

Centre for Radiation Protection Research (CRPR). Department of Genetics, Microbiology and Toxicology (GMT). Toxicology Prof. Thomas Helleday Prof. Ulf Rannug Prof. Dag Jenssen. Radiation Biology Prof. Andrzej Wojcik Prof. Mats Harms-Ringdahl. Molecular Mechanisms in Cancer.

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Department of Genetics, Microbiology and Toxicology (GMT)

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  1. Centre for Radiation Protection Research (CRPR) Department of Genetics, Microbiology and Toxicology (GMT) Toxicology Prof. Thomas Helleday Prof. Ulf Rannug Prof. Dag Jenssen Radiation Biology Prof. Andrzej Wojcik Prof. Mats Harms-Ringdahl Molecular Mechanisms in Cancer / Dag Jenssen, GMT

  2. Radiation Biology (AW & MHR) 2 Profs 1 Postdoc 5 PhD students 2 Master students Mechanisms of cellular and systemiceffects of exposure to ionising radiation EU grants Swedish Radiation Safety Authority

  3. Patient with severe side-effect following radiotherapy Radiation Biology (AW & MHR) Mechanisms of individual sensitivity toionising radiation: • Differences in DNA-damage response pathways between cohorts of patients with normal or severe healthy tissue reactions to tumour therapy. • Screening for polymorphisms in genes for DNA-repair, cell cycle regulation and apotosis • Search for diagnostic tools to identify the persons at risk.

  4. Radiation Biology (AW & MHR) What are the risks of radiation at low doses? Can we improve biological dosimetry? New technologies will determine doses with high precision? New biomarkers for DNA- damage response pathways Is the dose response curve non-linear? Identification of new response pathways for very low doses. ?

  5. Professor Thomas Helleday’s group SU group 1 Prof 10 Postdocs & senior scientists 8 PhD students 1 Master students Oxford group 6 Postdocs 7 DPhil students DNA repair in cancer therapy Main grants from: Swedish Scientific Research Council (VR) Swedish Pain Relief Foundation (Smärtafonden) Swedish Cancer Foundation (Cancerfonden) Swedish Children’s Cancer Foundation (Barncancerfonden)

  6. SU - DNA Repair team Niklas Schultz, Helge Gad, Fredrik Johansson, Anne Lagerkvist, Linda Savolainen, Ingegerd Elvers, Cecilia Ström, Petra Groth, Firas Al-Ubadi, Ivaylo Stoimenov, Kristian Grimberg, Guoli Liu, Muntasir Mamun Research areas • Stalling of Replication fork and Replication Restart • Homologous recombination • DNA replication termination • DNA repair in cancer (cells + clinical material)

  7. SU - Biochemistry/proteomics SU – Cancer Biology Ann-Sofie Jemth, Olga Loseva Research areas • Poly (ADP ribose) polymerases • Proteomics after DNA damage • Purification of protein targets for cancer treatment Tatjana Djureinovic, Evgenia Gubanova Research areas • DNA damage signalling in cancer • Evaluation of targets for cancer treatment

  8. SciLifeLab - High-Throughput Screening SU – Medical Chemistry Bo Lundgren Research areas • RNAi library screens in cells • Identify targets for cancer treatments • Map functional genetic networks Martin Scobie, Tobias Koolmeister Research areas • Lead optimisation - Parallell organic chemistry synthesis

  9. Professor Ulf Rannugs group 1 Prof 1 Postdoc 3 PhD students 1 Master student Natural non-persistent bioactive aryl hydrocarbon receptor ligands in humans The Swedish research Council FORMAS

  10. Professor Ulf Rannug, cont. AhR NFĸB Formation and metabolism of the suggested physiological Ah receptor ligand 6-formyl-indolo[3,2-b]carbazole (FICZ) HPLC, LC/MS/MS Recombinant human enzymes Human cells in vitro Human blood, plasma and urine samples

  11. Professor Ulf Rannug, cont. TRYPTOPHAN OTHER RECEPTORS (LXR) TRYPTAMINE PROLIFERATION/APOPTOSIS The new AhR paradigm DEVELOPMENT I-3-A DIFFERENTIATION Genomic and non-genomic regulation HOMEOSTASIS FICZ IMMUNERESPONS ARYL HYDROCARBON Active ligand RECEPTOR (AhR) INFLAMMATION STRESS RESPONSES CYP1 AOX NEUROENDOCRINE oxFICZ SECOND FUNCTIONS Inactive ligand MESSENGERS

  12. Professor Dag Jenssen’s group 2 Profs 2 Postdocs 2 PhD students 3 Master students Molecular/cellular mechanisms for induced mutations EU grants Swedish Cancer Society Swedish Radiation Protection Authority / Dag Jenssen, GMT

  13. Professor Dag Jenssen, cont. Mechanisms involved in the repair of genomic DNA intra-strand cross-links (Cf, 2010-2013) Cell culture models DNA repair DNA replication Mutation assay DNA sequencing The basis for cancer risk assessment of lifestyle factors / Dag Jenssen, GMT

  14. Professor Dag Jenssen, cont. Molecular/cellular protection mechanisms against carcinogenic constituents in food (EU, 2010-2014) The basis for developing Functional Foods / Dag Jenssen, GMT

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