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Results of laboratory studies on RF fields Prof. Dr. Alexander Lerchl

Results of laboratory studies on RF fields Prof. Dr. Alexander Lerchl Jacobs University Bremen, Germany Head , Commission on Non-Ionizing Radiation, German Radiation Protection Board (SSK). Actions of EMF on Organisms – Theoretical Targets. Cancer. Brain ( e.g ., Growth Hormone,

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Results of laboratory studies on RF fields Prof. Dr. Alexander Lerchl

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  1. Results of laboratory studies on RF fields Prof. Dr. Alexander Lerchl Jacobs University Bremen, Germany Head, Commission on Non-Ionizing Radiation, German Radiation Protection Board (SSK)

  2. Actions of EMF on Organisms– TheoreticalTargets Cancer Brain (e.g., Growth Hormone, LH, TSH, TRH, Melatonin) Thyroid Gland (Thyroxin) Whole Body (e.g., Temperature, Metabolism) Reproductive Organs (e.g, Testosterone, Estrogens)

  3. Actions of EMF – TheoreticalMechanisms WHO Research Agenda for Radiofrequency Electromagnetic Fields, 2010

  4. Cancer and Electromagnetic Fields in Animals withoutEMF ? withEMF Time

  5. Studies in AKR/J Mice (900 MHz) N=160 / group; SAR = 0.4 W/kg (24/7) Blindeddesign Sommer et al., BMC Cancer 4 (2005): 77

  6. Studies in AKR/J Mice (900 MHz) N=160 / group; SAR = 0.4 W/kg (24/7) Blindeddesign Sommer et al., BMC Cancer 4 (2005): 77

  7. Studies in AKR/J Mice (900 MHz) P<0.01 N=160 / group; SAR = 0.4 W/kg (24/7) Blindeddesign Sommer et al., BMC Cancer 4 (2005): 77

  8. Effects of EMF (900 MHz) on Metabolism in Hamsters (Pilot Study) Lerchl et al, BEMS 2008

  9. Studies in AKR/J Mice (1966 MHz; UMTS) N=160 / group; SAR = 0.4 W/kg (24/7) Blindeddesign Sommer et al., Radiat Res 168 (2007): 72 - 80

  10. Studies in AKR/J Mice (1966 MHz; UMTS) n.s. N=160 / group; SAR = 0.4 W/kg (24/7) Blindeddesign Sommer et al., Radiat Res 168 (2007): 72 - 80

  11. Mice Multigeneration Study(1966 MHz; UMTS) N=32 pairs (2 females, 1 male) per group; 4 exposuregroups (0, 0.08, 0.4, 1.3 W/kg); 4 generations; exposure 24/7; blindeddesign

  12. Mice Multigeneration Study(1966 MHz; UMTS) Sommer et al., Radiat Res 171 (2009) 89-95

  13. Mice Multigeneration Study(1966 MHz; UMTS) Sommer et al., Radiat Res 171 (2009) 89-95

  14. Mice Multigeneration Study(1966 MHz; UMTS) Sommer et al., Radiat Res 171 (2009) 89-95

  15. Effects of Head-OnlyExposure (900 MHz) on Development, Learning and Memory in Rats

  16. Effects of Head-OnlyExposure (900 MHz) on Development, Learning and Memory in Rats

  17. Effects of Head-OnlyExposure (900 MHz) on Development, Learning and Memory in Rats • N = 24 rats per group • SAR (brain) = 0, 0.4, 2 and 10 W/kg (blinded) • Exposure 2 h / day, 5 days / week • Exposurestarted at an age of 14 days (!) • Battery of behavioraltests: • 8-arm maze • Rotarodwheel • Open field • Water maze 3 timesduringexperiment: - juvenile (completed)- adult- pre-senile

  18. OddsRatios OR=1: Control Significantlyhigher Significantlylower A B C Condition (e.g., exposure) Oddsratio 95 % confidenceinterval (depends on groupsize!)

  19. SpontaneousBrain Tumors in Rodents Repacholi et al., 2012

  20. Brain Tumor Promotion in Rodents Repacholi et al., 2012

  21. Pituitary Tumors in Rodents Repacholi et al., 2012

  22. Conclusions • Studieslooking at theeffects of electromagneticfields in rodents so far didnotindicate an increasedriskforvariouscancers, even at levels well abovetherecommendedexposure limits. • Chronicexposure of AKR/J or normal mice (in a multigeneration study) revealed no adverseeffects on healthordevelopment at rather high SAR values. • Althoughanimalstudiesarelimitedwithrespect to humans, theyaddweight on thegeneralconclusionthat cancerogenic effects of EMF arehighlyunlikely.

  23. Acknowledgements • Projects funded by the Bundesamt für Strahlenschutz (BfS), Germany • Dr. Melanie Klose, Dr. Angela Sommer, Dr. Kirsten Schwarzpaul, Karen Grote, Thomas Ströhlein (Jacobs University) • Nina Kloss (Jacobs University, 2nd yearundergraduate, project on temperatures) • Volkert Hansen, Joachim Streckert, Andreas Bitz (Universities Wuppertal and Essen)

  24. Thankyouforyourattention!

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