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SPONSORS. Agilent TechnologiesApplied Biosystems/MDS SciexMicromassThermoFinniganWatersCalibration and Validation Group. MEETING Agenda:Dinner: 6:30pm -8:00pm
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1. CVG LC-MS Discussion Group Meeting“Feedbacks from the 50th ASMS Conference”Presented by: Dr.Fabio GarofoloEli Lilly Canada Inc. June 20th 2002Toronto, Canada
2. SPONSORS Agilent Technologies
Applied Biosystems/MDS Sciex
Micromass
ThermoFinnigan
Waters
Calibration and Validation Group
3. MEETING Agenda:
Dinner: 6:30pm -8:00pm
6:30-8:00pm – Oral presentations
6:30-6:45pm – CVG LC-MS Group Introduction (Fabio Garofolo)
6:45-7:00pm – Agilent Technologies (Richard Smith)
7:00-7:15pm – AB/MDS Sciex (Yves LeBlanc)
7:15-7:30pm – Micromass (David Heywood)
7:30-7:45pm – ThermoFinnigan (Steve Hassan)
7:45-8:00pm – Waters (John Vukovic)
6:00-9:00pm – Poster session. (Authors present from 8pm to 9pm).
Adjourn
4. Agenda:
CVG Discussion Groups
LC-MS Discussion Group
Review of the minutes from previous Meetings
1st on Jan 24th 2001
2nd on March 21st 2001
3rd : “Feedbacks from the 50th ASMS”
Next meeting at the “CVG/TPD International Convention on Quality of Pharmaceutical” on Sept. 19- 20, 2002.
Q & A
5. Background Based upon the success of the CVG Pharmacopoeial Discussion Group
Four CVG Discussion Groups
Pharmacopoeial
Impurity
Dissolution
LC/MS
6. Objectives provide a forum for free exchange of scientific information
solicit feedback on best practices
discuss proposed guidelines from different regulatory agencies
7. Scope of the LC-MS discussion group Only in the GTA there are more than 800 scientists involved in LC-MS
Bioanalytical (pharmacokinetics, pharmacology, Toxicology, Metabolism)
Analytical (pharmaceutical and environmental )
Proteomics
8. How to achieve our goals? All personal information will be kept strictly confidential, and this information will NOT be documented in the minutes.
All opinions are those of the individual, and do not reflect that of their company.
The membership of each discussion group will be kept below 60. This is to ensure each member will have the chance to participate actively in the discussion.
In each discussion group, there will be not more than 5 members from the same company. This is to ensure we will receive opinion from many different companies.
9. How can you help? Encourage your colleagues to join
Participate actively in the discussion
Suggest discussion topics
Facilitate some discussions in upcoming meetings
Provide feedback about the effectiveness of the discussion
10. Plan for upcoming meetings One meeting every ~2 months
Meeting duration: 6pm-9pm
Location: hotel, convention centre or company
Each meeting will schedule 3 discussion topics (Bioanalytical, Analytical and Proteomics)
Agenda will be sent in advance
Minutes will be published
Jan., Mar., Nov.: 1 sponsor per meeting
June: Special Meeting after ASMS meeting
Sept.: Special meeting at CVG convention
11. Role and responsibility Coordinators:
For LC-MS
Dr.Fabio Garofolo (Eli Lilly)
For CVG
Dr. Chung Chow Chan (Eli Lilly)
Dr. Herman C. Lam (GlaxoSmithKline)
Area Topic Leaders:
Bioanalytical
Dr. Henrianna Pang (Eli Lilly)
Dr. Adan Effio (Novopharm)
Analytical
Dr. Nick Toltl (Eli Lilly)
Proteomics
Dr. Bev Incledon (Eli Lilly)
Prof. Michael Siu (York University)
12. Jan. and Mar. meetingsCompanies represented: Agilent Technologies,
Apotex
AB/MDS Sciex,
Biovail Contract Res.
Bodycote Canada Inc.,
Eli Lilly Canada,
Novopharm, 8. Patheon,
9. Pharma Medica,
10. Ray &Berndtson Inc.
11. ThermoFinnigan
12. Unilever Canada
13. York University
13. TOPICS discussed: BIOANALYTICAL
Atmospheric Pressure Ionization LC-MS/MS: short run times and high sample throughput
Impact of Biotransformation in Bioanalytical Assays
ANALYTICAL
Data Dependent Experiment
PROTEOMICS
Nanospray vs MicroESI in Proteomics
14. “Feedbacks from the 50th ASMS Conference” The purpose of the meeting is to share and collect feedbacks from the 50th ASMS conference.
There are posters presented by Canadian scientists and sponsoring LC-MS manufacturers and leading companies, which were introduced at the ASMS Conference in Florida
15. Next meeting: Joint CVG/Therapeutic Products Directorate (TPD)“International Convention on the Quality of Pharmaceuticals and Exhibitions” (Toronto, Canada, September 19 & 20)
SESSION 4 LC-MS applications
Carry-over in Bioanalytical Methods
Protein in Mass Spectrometry and Proteomics
Validation of Bioanalytical Methods
LC-MS in Environmental Analysis
16. Next meeting: “International Convention on the Quality of Pharmaceuticals and Exhibitions”
Registration fees:
Includes Continental Breakfast, Lunch and Refreshments
It is free for all LC-MS Discussion Group registered members
(if you have already paid the fee for the LC-MS discussion group you don’t need to pay the convention registration fee)
17. For More Information: About CVG activities and discussion groups,and training, check:
www.cvg.ca
About LC-MS discussion group & LC-MS training courses check:
www.cvg.ca
www.csms.inter.ab.ca
18. CVG LC-MS Discussion Group Meeting“Feedbacks from the 50th ASMS Conference”Presented by: Dr.Fabio GarofoloEli Lilly Canada Inc. June 20th 2002Toronto, Canada