1 / 14

Developmental stage-specific biphasic roles of Wnt signaling

Developmental stage-specific biphasic roles of Wnt signaling. in cardiomyogenesis and hematopoiesis. (Atsuhiko T. Naito et al, 2006, Development ). Wnt signalings in embryonic development. Zygotically expressed wnt8 may be involved in specifying or patterning ventral mesoderm.

reid
Download Presentation

Developmental stage-specific biphasic roles of Wnt signaling

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Developmental stage-specific biphasic roles of Wnt signaling in cardiomyogenesis and hematopoiesis (Atsuhiko T. Naito et al, 2006, Development)

  2. Wnt signalings in embryonic development Zygotically expressed wnt8may be involved in specifying or patterning ventral mesoderm. (Gregory M Kelly, 1995, Development) Members of the Wnt and Tgfβ/Bmp families play critical roles in anterior-posterior patterning (Yamaguchi TP, 2001, Curr Biol) Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo (Isaac skromne, 2001, Development) AP Axis patterning, primitive streak formation, mesoderm induction Wnt signaling

  3. Wnt signalings that related in development of mouse embryo (Kimelman D, 2006, nature)

  4. Development of Mouse embryo (Yamaguchi TP, 2001, Curr Biol)

  5. Many controversies about Wnt signaling in heart formation In chick embryo, Wnt signals from the neural tube block ectopic cardiogenesis (Eldad Tzahor, 2001, Genes & Dev) Dkk-1 can induce heart-specific gene expression in noncardiogenic mesoderm of Xenopus laevis (Valerie A., 2000, Genes & Dev) Heart development in Drosophila requires the segment polarity gene wingless(Wg). (Wu X, 1995, Dev Biol) Overexpression of Wg using heat shock promoter increases the amount of heart formation in Drosophila (Maiyon Park, 1996, Dev Biol)

  6. Overexpression of Wnt-1, 3causes on reduction of cardiomyocyte In chick embryo (Eldad Tzahor, 2001, Genes & Dev)

  7. Overexpression of Wgcauses on abundance of cardiomyocyte In gastrula of Drosophila (Park M, 1996, Dev Biol) about a fourfold increase of heart precusor cell occurs in hswg embryos upon heat-shock for 30min at 37.5℃

  8. Hanging drop method

  9. Wnt Signaling promotes Cardiomyogenesis During Early Stage of ES Cell Differentiation.

  10. Wnt Signaling promotes Cardiomyogenesis During Early Stage of ES Cell Differentiation.

  11. Wnt Signaling inhibits Cardiomyogenesis During Late Stage of ES Cell Differentiation.

  12. Wnt inhibits cardiomyocyte differentiation in the late phase by suppressing BMP signaling.

  13. Modulation of Wnt Signaling Enables Efficient Induction of Cardiomyocytes from ES Cells.

  14. Wnt signals exhibit developmental stage-specific, biphasic, and antagonistic effects on cardiogenesis and hematopoiesis. (Yamaguchi TP, 2001, Curr Biol)

More Related