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T. Husøy, M. Haugen, M. Murkovic , D. Jöbstl, L.H. Stølen, T. Bjellaas,

EUROPEAN COMMISSION. FOOD QUALITY AND SAFETY. Dietary exposure to HMF from Norwegian food and correlations with urine metabolites of short-term exposure. Graz University of Technology Institute of Biochemistry Functional Food Group.

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T. Husøy, M. Haugen, M. Murkovic , D. Jöbstl, L.H. Stølen, T. Bjellaas,

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  1. EUROPEAN COMMISSION FOOD QUALITY AND SAFETY Dietary exposure to HMF from Norwegian food and correlations with urine metabolites of short-term exposure Graz University of Technology Institute of Biochemistry Functional Food Group T. Husøy, M. Haugen, M. Murkovic, D. Jöbstl, L.H. Stølen, T. Bjellaas, C. Rønningborg, H. Glatt, J. Alexander Food and Chemical Toxicology 46 (2008) 3697–3702

  2. proposed pathway O O O S O H O O Sulfotransferases O O O Oxidation main pathway in kidneys and urinary excretion H O O O O H Metabolism of HMF

  3. DNPH-derivatives of HMF

  4. Chromatogram of HMF-DNPH in urineRP, 400 nm

  5. Renal excretion of HMF

  6. GC analysis of HMFA in urineafter silylation with BSTFA/TMCS

  7. HMF and HMFA

  8. Chromatogram of HMF and HMFA in urine

  9. Study design • 47 non-smokers + 6 smokers (2 ♂, 4 ♀) (53 participants) • 24 h dietary recall • 24 h collection of urine • 20 ♂ (45  13) + 33 ♀ (41  11) • Foods (35) from the 24 h dietary recall were purchased and analysed for HMF and HMFA • 26 contained HMF and 10 HMF

  10. Norwegian brown cheese Jam and honey Cereal products Dried fruits Fruit juices Coffee Beer Coffee Cereal products Food groups containing HMF and HMFA

  11. HMF and HMFA in Norwegian food products Husøy et al., 2008

  12. Contribution of single food groups to the uptake of HMF

  13. Estimated 24 h dietary intake and 24 h urinary excretion of HMFA Husøy et al., 2008

  14. Correlationbetween 24 h dietary intake of HMF, HMFA, HMF + HMFA, coffee, dried fruits and beer, and 24 h urinary excretion of HMFA (n = 53) rsp = Spearman’s rank correlation coefficient. Husøy et al., 2008

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