Update on Alopecia Areata Research

1. CANAAF COME TOGETHER 2016. Toronto, ON Update on Alopecia Areata Research What’s New ? Jeff Donovan MD PhD FRCPC Dermatologist Assistant Professor, University of Toronto

2. Five new studies to discuss • Can cholesterol medications help alopecia areata? • What is platelet rich plasma (PRP) and can it help? • Can glaucoma medications help? • Are steroid injections better than topical steroids? • Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

3. Five new studies to discuss • Can cholesterol medications help alopecia areata? • What is platelet rich plasma (PRP) and can it help? • Can glaucoma medications help? • Are steroid injections better than topical steroids? • Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

4. Can cholesterol medications help alopecia areata?

5. STATINS • Lower cholesterol • Reduce inflammation

6. STUDY Highlights • 19 patients • Treated with simvastatin and ezetimibe 24 weeks • 75 % improved hair • Stopping the drug lead to hair loss Treatment of alopecia areata with simvastin/ezetimibe. Journal of the American Academy of Dermatology 2015

7. Five new studies to discuss • Can cholesterol medications help alopecia areata? • What is platelet rich plasma (PRP) and can it help? • Can glaucoma medications help? • Are steroid injections better than topical steroids? • Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

8. What is Platelet rich plasma ?

9. PRP as a new option

10. Journal of the American Academy of Dermatology Case Reports 2015

11. Five new studies to discuss • Can cholesterol medications help alopecia areata? • What is platelet rich plasma (PRP) and can it help? • Can glaucoma medications help? • Are steroid injections better than topical steroids? • Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

12. Topical Bimatoprost

13. STUDY Highlights • 9 year old female • Used minoxidil, steroid injections topical steroid without improvement Successful Treatment of Pediatric Alopecia Areata of the Scalp with Topical Bimatoprost Solution Pediatric Dermatology 2016

14. 1 drop per patch twice daily Regrowth at 1 month; full at 7 months

15. Five new studies to discuss • Can cholesterol medications help alopecia areata? • What is platelet rich plasma (PRP) and can it help? • Can glaucoma medications help? • Are steroid injections better than topical steroids? • Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

16. STUDY Highlights • 226 patients • 113 receiving steroid injections • 113 received topical steroids • Better hair growth in those receiving steroid injections Intralesional triamcinolone acetonidevs topical betamethasone valerate in the management of localized alopecia areata. J Coll Physicians Surg Pak 2015

17. Five new studies to discuss • Can cholesterol medications help alopecia areata? • What is platelet rich plasma (PRP) and can it help? • Can glaucoma medications help? • Are steroid injections better than topical steroids? • Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

18. The JAK KINASES J Invest Dermatol. 2014 Dec;134(12):2988-90. Craiglow BG1, King BA1.

19. STUDY Highlights • 35 year old male • Vitiligo and alopecia areata • Hair regrowth starting at 4 weeks and signficant by three months Harris JE. Rapid skin repigmentation on oral ruxolitinib in a Patient with coexistent vitiligo and alopecia areata (AA). Journal of the American Academy of Dermatology Feb 2016

20. STUDY Highlights Craiglow BG et al. Topical ruxolitinib for the treatment of alopecia areatauniversalis. JAMA Dermatology April 2016

21. CANAAF COME TOGETHER 2016. Toronto, ON JULY 23, 2016 Update on Alopecia Areata Research So, what’s new ? Jeff Donovan MD PhD FRCPC Dermatologist Assistant Professor, University of Toronto