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Vertebrate Embryonic Patterning 4

Vertebrate Embryonic Patterning 4 . Mesoderm & Ectoderm Duke It Out in Neural Induction. Neuralizing Mesoderm Signals. Neural Specification by Mesoderm Factors. Mesoderm cells secreting noggin, cerberus, and chordin deplete BMP from overlying ectoderm.

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Vertebrate Embryonic Patterning 4

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  1. Vertebrate Embryonic Patterning 4 Mesoderm & Ectoderm Duke It Out in Neural Induction

  2. Neuralizing Mesoderm Signals

  3. Neural Specification by Mesoderm Factors Mesoderm cells secreting noggin, cerberus, and chordin deplete BMP from overlying ectoderm

  4. Posteriorization of Mesoderm & Neural Tube • Substances must exist that specify anterior neural tissue vs posterior neural tissue • Brain vs spinal cord • Regionalization of the neural tube • Forebrain, midbrain, hindbrain, spinal cord

  5. Einstuck Experiments Showing Commitment of Meso/Neural Tissues

  6. Induction Properties of Dorsal Lip Change During Gastrulation

  7. Posteriorization of Implanted Neuroectoderm

  8. Retinoic Acid Posteriorizes Embryos

  9. Xwnt 3A Posteriorizes

  10. Overall Scheme (Hypothetical)

  11. Hox Genes Pattern A-P Axis

  12. Drosophila Homeotic and Vertebrate Hox Genes Expression Domains Correspond Anterior genes are Otd = Otx 1&2 Ems = Emx 1&2 Vertebrate Differences in Pair-rule genes En – mid/hindbrain boundary Prd = many Pax genes some specify anterior fields like eye & otic vesicle

  13. Neural Tube Formation I

  14. Neural Tube Formation II

  15. Neural Tube Formation in Chick

  16. Classical Meets Molecular

  17. Dorsal-Ventral Patterning

  18. Roofplate shh – green dorsalin – blue Motor neurons Floorplate Notochord

  19. Specification of Spinal Cord Neurons

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