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 ~ 30 - 40% of the genes of an organism code for membrane proteins

 ~ 70% of current pharmaceuticals target membrane proteins.  ~ 30 - 40% of the genes of an organism code for membrane proteins.  ~ 110 structures of membrane proteins; whereas over 30,000 structures of globular proteins in the RSCB Protein Data Bank. Pancreas cell. Topography Mapping:

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 ~ 30 - 40% of the genes of an organism code for membrane proteins

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  1. ~ 70% of current pharmaceuticals target membrane proteins ~ 30 - 40% of the genes of an organism code for membrane proteins ~ 110 structures of membrane proteins; whereas over 30,000 structures of globular proteins in the RSCB Protein Data Bank Pancreas cell

  2. Topography Mapping: Proteolytic Cleavage Chemical Labeling Sequence Prediction Accessibility Measurements

  3. Membrane Protein Topography beta-barrel alpha helical Stephen White website: UC Irvine http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html

  4. AbstractThe structure of the Staphylococcus aureus alpha-hemolysin pore has been determined to 1.9 A resolution. Contained within the mushroom-shaped homo-oligomeric heptamer is a solvent-filled channel, 100 A in length, that runs along the sevenfold axis and ranges from 14 A to 46 A in diameter. The lytic, transmembrane domain comprises the lower half of a 14-strand antiparallel beta barrel, to which each protomer contributes two beta strands, each 65 A long. The interior of the beta barrel is primarily hydrophilic, and the exterior has a hydrophobic belt 28 A wide. The structure proves the heptameric subunit stoichiometry of the alpha-hemolysin oligomer, shows that a glycine-rich and solvent-exposed region of a water-soluble protein can self-assemble to form a transmembrane pore of defined structure, and provides insight into the principles of membrane interaction and transport activity of beta barrel pore-forming toxins.

  5. TolC

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