The Sheba Medical Center sheba.co.il

1. The Sheba Medical Center www.sheba.co.il

2. Sheba Medical Center at Tel Hashomer Israel's National Medical Center Sheba Medical Center - Facts and Figures • Comprises 120 departments and clinics, 1,800 beds, 6,800 healthcare professionals, including 900 doctors and 2,000 nurses. • Comprehensive care - an Acute Care Hospital with a Rehabilitation Hospital, Maternity Hospital, Children's Hospital, Medical Research Laboratory Complex, and an Academic Campus. • 1.5 million patient visits a year, including 175,000 emergency visits, 90,000 inpatients and 2 million medical tests each year. • Situated on a 150-acre campus.

3. Sheba Medical Center at Tel-Hashomer Israel's National Medical Center Research at Sheba • 3200 researchers, technicians and lab workers • 25% of Israeli medical research is performed at Sheba • 600 clinical trials per year (200 industry-sponsored) • 400 published articles per year • The main venue for human clinical trials conducted by the Weizmann Institute, Tel Aviv and Bar-Ilan universities. • 25 M$ /year income from grants, sponsored-research, donations • 81 biomedical patents, 37 licensed patents

4. Sheba Medical Center at Tel-Hashomer Israel's National Medical Center Our Research Facilities (Pre-Clinical) • 75 laboratories spanning 35,000 m2 area • 9 ISO-15189 approved laboratories • IVC-SPF small animal facility • Zebra fish facility • Genomic center equipped with last-generation genome analyzers and microarray facilities • Advanced Microscopy Unit (multiphoton, microdissection, electron and confocal microscopes) • Tissue bank with over 15,000 specimens and depositions from over 400 new patients per year • Fully-automated MegaLab facility performing over 1000 different clinical tests • Surgery room for big animals with state-of-the-art equipment

5. Sheba Medical Center Research and Development Powerhouse Patent Committee R & D Unit Medical Research Centers TTO IP management & Commercialization Research & Licensing Research Funding Grant coordinator R&D collaborations Research info Commercial Clinical Sponsored Research Agreements Business Partners Business Partners

6. Sheba Medical Center Research Centers of Excellence • Research Center for Autoimmune Diseases • Research Center for Psychiatric and Dementia • Advanced Technology Center • Sheba Cancer Research Center • Regenerative Medicine Research Center • The Bert W. Strassburger Lipid Center • The Joseph Sagol Neuroscience Center • The Leviev Heart Center • The Multiple Sclerosis Research Center • Imaging Institute • Tissue Banking – Research Tools

7. Sheba Institutional Tissue Bank The partner to accelerate Biomedical ResearchandMedical Product Developmentthrough clinical & database resources Orthopedics Lungs Thoracic Thymus Sheba Tissue Bank Brain Kidney Urology Bladder Breast Surgery Adrenal Prostate GI Head and Neck Hepato -biliar Children Thyroid Larynx Gynecology Nasal sinus Pharynx Melanoma All solid tumors Ovary ‘Hemato’ Bm & Bx Uterus

8. Research & Development at Sheba Collaboration with Research Institutes Weizmann Institute of Science Tel Aviv University Bar Ilan University MD Anderson, University of Texas Cedars-Sinai Medical Center Mayo Clinic Cincinnati Children's Hospital Medical Center The Cleveland Clinic Medical Center Albert Einstein - Brazil

9. Sheba Medical Center Commercial & Clinical Studies at Sheba

10. Sheba Medical Center a Medical Research Powerhouse Competitive Grant Sponsored Research at Sheba

11. Technology Transfer at Sheba • Guided devices for GI tract monitoring • Non-invasive identification of pathologic substances in amiotic fluid • Stem cell subretinal injector • Automatic classification of X-ray images • BBB disruption analysis by MRI • On-line assessment of tissue ablation • Cancer treatment by recombinant Klotho, CEACAM1, STIL • Synthetic peptides for APS • Bleeding treatment by Fibrinogen • Gene signatures for MS management / personalized medicine • Labeled somatostatin analogs • Serum markers for bone maladies

12. Sheba Medical Center Technology Transfer Activities Patent Commercialization Total Patent Family –89 Total Commercial agreements - 42 • Medical Device 20% • Therapeutics & Drug Delivery 15% • Biological Markers 25% • Imaging 15% • Stem Cells 25% *15 patent applications were abundant

13. Research & Development at Sheba Collaboration with the Industry Ani-Biofilm compounds for Cleantech and medical applications HUTCHISON WHAMPOA LIMITED Novel Therapy for Blindness & Psoriasis NIKKEN SOHONSHA Corporation Production of antibodies to cellular proteins SIGMA-ALDRICH ISRAEL Ltd Antibodies to treat Melanoma PONTIFAX and F. HOFFMANN-LA ROCHE Ltd. Aortic Valve Implantation VENTOR-MEDTRONIC Convection-Enhanced Drug Delivery and MRI MonitoringSchering-Plough Apparatus for guiding medical devices in the GI I. P. U Industrial, Israel

14. Research & Development at Sheba Collaboration with the Industry • High-intensity focused ultrasound • InSightec • Antibodies to FRZ 7 • Sigma • SiRNA to STIL gene – cancer treatment • Bioline • miRNA for Cancer Diagnostic • ROSETTA GENOMICS • Stem Cell Therapy for Renal Failure • Wolfson Clore Mayer VC • Novel Papilometer – Field View Analysis • ACCUTOME

15. Spinoff Companies • Nephrostem – cell therapy to treat renal failure • CCAM Medical – novel treatment for melanoma • MitralHeal - transapical mitral valve • Amniotix - spectral analysis of amniotic fluid • Radiologic - Automatic medical imaging analysis • Selpix - novel hair removing device • TopDyn - multiple sclerosis disease management • Orgenesis - cell therapy to treat diabetes

16. THM IP Portfolio Medical Devices Monitoring Ablation of Tissues Guiding Medical Devices in the Gastrointestinal Tract Improved Electron Radiotherapy Identification of Meconium in Amniotic Fluid Novel diagnostic pill for GI applications Objective Chromatic Perimetry Analysis Using Pupillometer

17. THM IP Portfolio Medical Devices METHOD AND DEVICE FOR DETECTION OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT Subretinal Injection Device Methods and Devices Suitable for Imaging Blood-Containing Tissue Transapical Mitral Valve Left Atrial Appendage Intra-atrial Clip Colostomy Ileostomy Automatic Stapler Device

18. THM IP Portfolio Therapeutics Klotho: Tumor suppressor of breast and pancreatic cancers Targeting CEACAM1 for Cancer Therapy Anti-Cancer Treatment - siRNA to STIL Somatostatin Analogs – Platform for targeting Drugs Cardiac Scar Rejuvenation by Chemical Peeling Synthetic Peptide For Antiphospholipid Syndrome Cancer Treatment with Exendin 4 Bleeding Treatment by Fibrinogen Targeting Multiple Sclerosis - Si RNA to specific Target genes Specific microRNAs (miRNA) selection for psoriasis treatment Novel Target to treat Cancer Stem Cells

19. THM IP Portfolio Diagnostics Transcriptional Signatures for Multiple Sclerosis Management Gene Signatures for Brain Metastasis Prediction Methods and Kits for Determining Predisposition to Warfarin Resistance Human Serum markers for Bone Formation and Bone Maladies Somatostatin analog for Cancer Diagnosis and Treatment Trophoblast Markers for non-invasive Prenatal Diagnosis Methyl-Tetrahydrofolate homocystein Methyl Transferase – MTR as a marker for autoimmune diseases Klotho Mutations in Breast Cancer

20. THM IP Portfolio Stem Cells Stem Cell Therapy for Renal Failure Cell Therapy for Diabetes Stem Cells for Cardiac Applications Recovery of all stem, progenitor and regenerative cells Enrichment and Expansion of Human Stem Cells from peripheral blood and umbilical vein cord blood

21. THM IP Portfolio Imaging Automatic Analysis of X-rays by “Bag of Visual Words” Algorithm Method and System for Monitoring Ablation of Tissues BBB Disruption Assessment by MRI

22. THM IP Portfolio Biological Tools Drug Discovery Platform for MS Drugs Methods for Silencing Gene expression In vivo Tool to Identify Novel Targets in Health and Disease useful for Drug Screening based on A-I RNA editing ERG transgenic mouse - a platform for preclinical studies of novel therapeutics Immunoassay for Monitoring Patient’s Response to Biological Drugs Dynamic Contrast MRI for assessment of Blood Brain Barrier Convection – Enhanced Drug Delivery Small Scale Affinity Method for Biomarker Enrichment in Human Serum