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Lecture 13 Post-transcriptional processing of mRNA Membranes again

Lecture 13 Post-transcriptional processing of mRNA Membranes again. Post-transcriptional Gene control (Chapter 8). hnRNP proteins coat the RNA immediately upon its exiting from RNA polymerase Human hnRNP A1 (red) and C (green) proteins distribute differently in the cytoplasm of a heterokaryon.

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Lecture 13 Post-transcriptional processing of mRNA Membranes again

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  1. Lecture 13 Post-transcriptional processing of mRNA Membranes again

  2. Post-transcriptional Gene control (Chapter 8)

  3. hnRNP proteins coat the RNA immediately upon its exiting from RNA polymerase Human hnRNP A1 (red) and C (green) proteins distribute differently in the cytoplasm of a heterokaryon

  4. Consensus sequence around splice sites

  5. The chemistry of RNA splicing

  6. The mutated mismatched A is in this position

  7. Exonic splicer enhancers Average length of intron ~3500 bases exons are ~ 150 bases long SR proteins (serine-arginine rich) interact with exonic splicing enhancers, mediate cooperative binding U1 snRNP to a true 5’ splice site. This helps forming cross-exon recognition complex

  8. Membranes and lipids Wikipedia Functions: compartmentation, maintain internal milieu, transport, energy transduction, signal propagation, cell-cell communication, ingestion, secretion, sensation, storage etc.

  9. Staining artifact due to binding of a contrasting agent (Uranyl or Osmium) to the polar headgroups Membranes are self-organizing structures

  10. (Phospholipids) glycerol PE, PC: zwitterions, PS:anionic PS and PE have H-bonding capacity

  11. Phosphatidic acid (PA) Phosphatidyl glycerol (PG)

  12. Phosphatidylinositol Phosphatidylinositol diphosphate (PIP2)

  13. Critical trans double bond sphingosine ceramide NH

  14. Cholesterol

  15. Lipids have their spontaneous curvature

  16. Micelles, Liposomes and Lamellar phases SDS

  17. Lipid Bilayers are dynamic distributions of phosphate and carbonyl groups and lateral pressure profiles From S. Feller

  18. Distribution of groups along the z-axis from S. White

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