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Data Sharing of Basic Medicine in China

THE FIFTH CHINA-US ROUNDTABLE ON SCIENTIFIC DATA COOPERATION. Data Sharing of Basic Medicine in China. Heng Wang, Professor, Director Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College ， Beijing, 2011-10-27.

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Data Sharing of Basic Medicine in China

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  1. THE FIFTH CHINA-US ROUNDTABLE ON SCIENTIFIC DATA COOPERATION Data Sharing of Basic Medicine in China Heng Wang, Professor, Director Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College ，Beijing, 2011-10-27

  2. ABOUT BMICC BioMedical Informatics Center of China

  3. Molecule --Individual--Population Scientists in all of the world 24 hour service Original scientific data produced in China

  4. Integrated and Shared 29 databases ◙Population Survey Database (8) ◙Molecular Mechanism Database (14) ◙Biomodel Organism Database (5) ◙Experiment Material Data Resource (2)

  5. Sharing Database (1)

  6. Sharing Database (2)

  7. Sharing Database (3)

  8. Sharing Database (4)

  9. Sharing Database (5)

  10. Sharing Database (6)

  11. Online Tools ◙ MiRAlign ◙MethCGI ◙ SubMito ◙PhoScan

  12. Resources of Data Original Requirements Quality

  13. Data from Laboratory

  14. Data from Cell Laboratory

  15. Data from Health Survey

  16. Chinese physiological reference dataset Population: 130,000 Provinces: 9 Races: 8 Variables in dataset: 247

  17. Zhejiang Ningxia Heilongjiaang Inner Mongolia Hebei Sichuan Hunan Yunnan Guangxi Distribution of areas for physiological reference survey in China

  18. Yan Huang database

  19. Yan Huang database (Beijing Genomics Institute at Shenzhen ) • The genome, named as YH, is a very start of YanHuang Project, which aims to sequence 100 Chinese individuals in 3 years. • To illustrated the personal genome data in a MapView, which is powered by GBrowse. • A new module was developed to browse large-scale short reads alignment. This module enabled users track detailed divergences between consensus and sequencing reads.

  20. Yan Huang database • Efforts on designing the YH database are helpful attempts to organize and present personal genome data, which is a useful resource for genomic and medical researches. • As the third published personal genome, YH diploid genome accelerates the discovery of disease gene and mutation in Asian population.

  21. Yan Huang database

  22. Maternal and Child Nutrition Reference Database

  23. Maternal and Child Nutrition Reference Database • Population Child and women in 14 provinces, China • Information Incidence of low birth weight Incidence of anaemia in reproductive aged women Prevalence of Vitamin A deficiency in child • Self-evaluation Fetus weight Anaemia in reproductive aged women Vitamin A deficiency in child

  24. A database on genetically engineered mouse and mouse models • Introduction • Reproductive information • disease models • Special use • Reference

  25. News of research on life sciences

  26. GOAL OF BMICC ★To create a national scientific data sharing center for biomedical information ★To establish the technical platform for integrating and sharing the scientific data ★ To collect and integrate more valuable and available databases related to the study on health and diseases in China ★ To provide the data sharing services for various users in different requirements

  27. Co-Units 13 institutes/universities, 5 provinces, • Institute of Basic Medical Sciences, CAMS • Center for Bioinformatics in Peking University; • Institute of Biophysics of CAS; • Institute of Computing Technology of CAS ;  • Beijing Genomics Institute ; • Beijing Genomics Institute at Shenzhen • Bioinformatics Division Tsinghua University;

  28. Co-Units • Beijing Proteome Research Center; • Model Animal Research Certer of Nanjing University • Capital Institute of Pediatrics; • Third Military Medical University ; • Fuwai Hospital, CAMS • Institute of Hydrobioloty , Chinese Academy of Sciences

  29. Sharing & service

  30. Browse Record Distribution by Month

  31. Browse Record Distribution by Countries

  32. Distribution of users all of the world

  33. VISITERS from all of the world --- Oct. 20th, 2011 520,596 person-times

  34. User groups in China • Scientists / specialists • Health officials • Students • Public

  35. Administration Model

  36. Institutes in CAMS & PUMC • Institute of Basic Medical Sciences • Institute of Medical Information • Institute of Laboratory Animal Science • Institute of Clinical Medicine • Institute of Oncology • Institute of Cardiovascular Disease • Institute of Plastic Surgery • Institute of Hematology • Institute of Dermatology • Institute of Materia Medica • Institute of Medicinal Biotechnology • Institute of Medicinal Plants • Yunan Branch • Hainan Branch • Institute of Microcirculation • Institute of Radiation Medicine • Institute of Blood Transfusion • Institute of Medical Biology • Institute of Biomedical Engineering • Institute of Pathogen Biology

  37. Public Health Center BMICC Clinical Center Traditional Medicine Drug Center Local Link National Medical Scientific data Sharing Network www.ncmi.cn Internet Internet Technology platform Resource system Standards Monitor and evaluation Users Users

  38. 交换机

  39. JOINY CONFERENCE Authoritativeness ◘ Strategies ◘Aim and assignment of the sub-centers ◘Financial plan ACADEMIC COMMITTEE Academic activities ◘Technical advisory ◘Monitor and revise ◘Evaluation MANAGEMENT OFFICE Implementation ◘Routine activities ◘Collect and integrate database ◘ Maintain the work on technique platform and network

  40. Work team

  41. RULES AND STANDARDS (1) ☆ Technical standards for data sharing ☆ The metadata standards ☆ The terminological standards in medicine ☆ The standards on the quality control for data searching

  42. ☆ The service guide ☆A manual for developing technique framework ☆Guide for data set execution. ☆A rule for data backup management RULES AND STANDARDS (2)

  43. Challenge and development

  44. Challenge ★Impact on biomedical researchers ★Weaker consciousness on sharing among researchers ★Requirement for specialists on cross- sciences (biomedical and computer science) ★Financial support on maintaining the network for a long term development

  45. ★ Continuing to search new data ★ To improve performance of technique platform ★ To develop the conjunction among datasets ★ International communication & cooperation ★ Wireless access supporting ★ Online self-evaluation on health Plan for the next step

  46. THANK Y0U

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