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Dry Cow Therapy, Mastitis and Milk - Enhancement

Dry Cow Therapy, Mastitis and Milk - Enhancement. Therapeutic treatment with casein hydrolyzate eradicate effectively bacterial infection in treated mammary quarters in cows. Nissim Silanikove , Agricultural Research Organization, Institute of Animal Science, Israel.

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Dry Cow Therapy, Mastitis and Milk - Enhancement

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  1. Dry Cow Therapy, Mastitis and Milk - Enhancement Therapeutic treatment with casein hydrolyzate eradicate effectively bacterial infection in treated mammary quarters in cows Nissim Silanikove, Agricultural Research Organization, Institute of Animal Science, Israel. Gabriel Leitner, The Veterinary Institute, Israel Jose Iscovich, Mileutis Ltd. Doron Tiomkin, Hchaklait, Veterinarian Services, Israel. Adin Swhimmer, CentralLaboratory for Udder Health, Israel.

  2. Treated Gland Control Gland Histology of gland treated with casein hydrolyzate (CNH) vs. non-treated gland

  3. CNH in Goats: Precipitous drying of milk secretion only in the treated gland Silanikove et al, Life Sci., 2002

  4. Secretion of large number of activated neutrophils. Enhanced secretion of immunoglobulins. Formation of bactericide environment: Secretion of antimicrobial proteins and free radicals formation. Drastic reduction in lactose and citrate concentration: elimination of food for bacteria. The Physiological Basis Dramatic activation of the innate immune system within 8 hours

  5. Evacuate the treated gland and infuse the drug into the cistern. Repeat the treatment twice over two days. Don’t milk between treatments. After the last treatment the gland is not milked until the next lactation. Treatment procedures

  6. Antibiotic treatment is not effective. The common treatment is to cut the teat in order to drain the infection or to treat with chlorhexidine or povidone - iodine. Without treatment the infection might spread and become lethal. Clinical mastitis with Arcanobacterium pyogenes

  7. To pour or not to pour

  8. SCC - POST SCC - PRE Average Average Staphylococcus aureus 5 1,235.2 147.4 All Streptococcus 1 7 3,357.4 262.3 Escherichia coli 7 1,781.2 275.4 Arcanobacterium pyogenes 10 1,465.1 145.6 Others 6 3,283.5 226.7 All: Average SCC 2,210.2 205.0 Standard deviation 2,374.3 170.2 SCC (×1000) before treatment and 15 to 60 days after treatment in 45 cows Somatic Cell Counts Pathogens Number Note: SCC-PRE denotes pre-treatment somatic cell counts; SCC-POST denotes post-treatment somatic cell count. Pooled across herds (n=10) and period, 2001-2003.

  9. 0 – 200 201 – 400 0 8 % Clinical 22 % 22% 8 % 40 % Subclinical 62 % 30% 8 % Total SCC (×1000) frequencies after treatment with CNH Stage >401

  10. 25.9 % 100 £ 33.3 % 101 - 200 201 - 400 25.9 % ³ 401 14.8 % SCC (×1000) frequencies after treatment with CNH in the following lactation Reminder : pretreatment average SCC was 2,210.2

  11. S. aureus 5 1 All Streptococcus 6 2 E. coli 4 1 pyogenesA. 10 0 Others 8 0 Total 33 4 Bacterial cure in cows treated with CNH Detected microorganism before treatment Detected microorganism after treatment Cure rate of 88.87 % P < .05

  12. Ontogenesis of milk production in cows treated with CNH Pooled across herds (n=10) and period, 2001-2003.

  13. The risk of new intramammary infections might be reduced if milk production decreased prior to dry off, the udder involuted rapidly, and the teat canal closed in a timely manner". R.T. Dingwell et al. 2001; National Mastitis Council Annual Meeting Proceedings, pp. 69-79; NMC, Verona, Wisconsin "For every 5 kg increase in milk yield at dry-off above 12.5 kg, the odds of a cow having an environmental intramammary infection at calving increased at least by 77%". Rajala-Schultz et al.; J Dairy Sci 2005; 88; 577-9 Dry period and new infections

  14. Dry off treatment: CNH vs. antibiotics SCC values

  15. S. aureus 3 0 0 0 S. dysgalactia 4 0 0 2 . chromogS 0 0 0 1 S. uberis 1 0 0 0 . coliE 1 0 0 1 CNS 2 0 0 2 Non infected post-treatment 100% 100% 45% Dry off treatment – infections in subsequent lactation Detected microorganism before treatment Detected SAME microorganism, 0-59 days after calving. Detected SAME microorganism 60-89 days after calving. Detected DIFFERENT microorganism 60-89 days after calving.

  16. Cow 2425

  17. Cow 2331

  18. Milk yield during the first 100 days in lactation in the year before and after dry period treatment 45.0 44.5 100% were bacterial free with SCC < 200,000 44.0 43.5 3.2 Liter\d increase 7.8% 43.0 42.5 42.0 3.7 Liter\d increase 9.36% Milk yield, L/d All cows were infected at end of lactation 41.5 41.0 40.5 40.0 39.5 39.0 38.5 20 30 40 50 60 70 80 90 100 110 Days in milking Values were corrected for lactation number

  19. Mean milk yield increase during first 100 days of lactation

  20. Conclusions CNH improve dramatically milk hygiene immediately, without the need to discard milk from the uninfected gland. CNH is effective where no alternative treatments exist. CNH gained high rate of bacterial cure, with secretion of milk with low SCC during the next lactation cycle. CNH is effective as a dry period treatment: eradicates existing infections, prevents new infectionsand lowers SCC. CNH shortens the dry cow period treatment. CNH increases milk yield.

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