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Turning Kinesin On the Unconventional Way

Turning Kinesin On the Unconventional Way. Jing Xu Gross Lab, UC Irvine. Macroscopic Machine. Coffee Maker Energy source Operation 1. Turn machine on. 2. Use feature. 3. Turn machine off. Nano-Machine. Molecular Motor: Kinesin-1 Energy source Operation? 1. Turn machine on?. +.

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Turning Kinesin On the Unconventional Way

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  1. Turning Kinesin On the Unconventional Way Jing Xu Gross Lab, UC Irvine

  2. Macroscopic Machine • Coffee Maker • Energy source • Operation • 1. Turn machine on. • 2. Use feature. • 3. Turn machine off.

  3. Nano-Machine • Molecular Motor: Kinesin-1 • Energy source • Operation? • 1. Turn machine on? + DG ~ -0.5 eV ~ -20 kBT Vale, Cell (2003)

  4. Cargo Conventional Wisdom: Head-Tail Interaction “Tail” “Head” Active “On” Autoinhibition “Off” Microtubule Hackney et. al, JBC (1992), Cai et. al, JCB (2007), Dietrich et. al, PNAS (2008), …

  5. Cargo Cargo Biology: There Exists Higher Order Regulation Inactive “Off” Active “On” Microtubule Welte et. al, Cell (1998), Shubeita et. al, Cell (2008), Encalada et. al, Cell (2011)

  6. Cargo Cargo Tail-Independent Inactivation, Reversible Inactive “Off” Active “On” Microtubule Xu et. al, Under Review

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