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RABIES VIRUS

RABIES VIRUS. What ’ s this?. Morphology and structure Replication Pathogenesis Clinical symptoms Diagnosis Prevention and Treatment. Morphology. bullet-shaped; 45-100 nm in diameter; 100-430 nm long. structure. Core -ssRNA L-protein (large protein)

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RABIES VIRUS

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  1. RABIES VIRUS

  2. What’s this?

  3. Morphology and structure • Replication • Pathogenesis • Clinical symptoms • Diagnosis • Prevention and Treatment

  4. Morphology • bullet-shaped; • 45-100 nm in diameter; 100-430 nm long.

  5. structure • Core-ssRNA • L-protein (large protein) • ---RNA dependent RNA polymerase RNP Capsid N-protein ---protect RNA from hydrolysis P-protein Envelope Bilipid layer • M-protein (matrix protein) • G-protein (glucoprotein) • ---spike • ---bind to the receptor of the host cell

  6. Rabies is an RNA virus. The genome encodes 5 proteins designated as N, P, M, G, and L. The order and relative size of the genes in the genome are shown in the figure below. The arrangement of these proteins and the RNA genome determine the structure of the rabies virus.

  7. Replication • Adsorption • Penetration • Uncoating • Biosynthesis • Assembly and release

  8. biosynthesis • -ssRNA • RNA polymerase • +ssRNA • -ssRNA protein • virus

  9. Pathogenesis • CNS afferent fibers efferent fibers nerve endings salivary gland Neuromuscular organs and tissues junction muscles Virus

  10. Clinical symptoms • Early stage (1-3days) • fever(37.5-38) • vomit • wound:pain,red,itching • Exciting stage(1-3days) • fever(39-40) • hydrophobia:pharyngeal muscle cramp,dyspnea • dehydration • Paralytic stage(15-20hs) • nerve fiber paralysis • respiratory and circulatory failure death

  11. Diagnosis • Pathogenic history • Isolating the dog(7-10days) cerebral smear or slice immunofluorescent stain

  12. Prevention and treatment • Kill wild dogs • Keep away from dogs • Clean the wound • Passive immunity • vaccine

  13. Bian Shu Cong Ping Mu Xueru Shao Cong Zhang Jingjing Zhu Wenying Cheng Wei Hu Chen Li Yuntao Li Daowei Wang Shengxi Contributers

  14. thank you!

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