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Amber Mix Life Cycle Nutrition

Influence of Mediterranean Diet on Asthma Symptoms, Lung Function, and Systemic Inflammation: A randomized Controlled Trial. Amber Mix Life Cycle Nutrition. Introduction. What is Asthma? A chronic inflammatory disease According to the CDC, 1 in 12 people in the US have asthma

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Amber Mix Life Cycle Nutrition

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  1. Influence of Mediterranean Diet on Asthma Symptoms, Lung Function, and Systemic Inflammation: A randomized Controlled Trial Amber Mix Life Cycle Nutrition

  2. Introduction • What is Asthma? • A chronic inflammatory disease • According to the CDC, 1 in 12 people in the US have asthma • Asthma is increasing in the US, just like obesity and diabetes • Typical symptoms are wheezing, itching throat, coughing, and short of breath

  3. Objective • Primary • Design and conduct a randomized trial assessing the feasibility of introducing adherence to the Mediterranean diet in adults with asthma. • Secondary • To access the effects of the Mediterranean diet on asthma symptoms, asthma-related quality of life, and systemic inflammation.

  4. Three Groups • High-intervention group: were encouraged to adopt MD and received intensive initial advice & 41-hr consultation sessions with a dietitian • Low-intervention group: received less intensive advice and spent 2-hr with a dietitian • Control group: offered just one session with a dietitian • Both intervention groups received written advice, olive oil, and vouchers for the purchase of MD foods

  5. Open Label Randomized Controlled Study • See Handout (flow chart) • Outcome Measures • Primary- endpoint was adherence to the Mediterranean diet, assessed by MDS • Other endpoints were used to examine the effect of intervention on asthma symptoms(AQLQ), asthma control (ACQ), and inflammation (biomarkers)

  6. Results • 35 out of 38 participants completed study • All three groups matched at baseline • HI group showed a significant increase in MDS, they reported eating more fruits, vegetables and fish, and less red meat and chicken compared to the control group • LI and Control group did not change during study • No changes is lung function or asthma control • HI group showed increase in several subdomains in AQLQ but were not statistically significant

  7. Results Continued • HI group showed a significant decrease in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol at the end of the study • No changes in any of the inflammatory biomarkers  • MDS did not correlate with lung function, AQLQ, ACQ, or any biomarkers

  8. Conclusion • The MD effect on asthma was of interest because the MD has anti-inflammatory properties • Primary objective was met, the HI gp did increase their MDS • TC and LDL cholesterol levels decreased in HI gp which is an effect of MD • Surprisingly, the LI gp showed no significant changes • Secondary objective was questionable, there were improvements but the improvements were not statistically significant

  9. Conclusions Continued • It may be that MD doesn’t improve asthma but possibly this intervention wasn’t strong enough • Also, MD might not improve/benefit the asthma itself but general quality of a persons life might improve • This study was done with adults, and maybe this study would have worked out in children • Also, these subjects already had asthma, maybe the MD could protect a person from developing asthma

  10. References • Sexton P, Black P, Metcalf P, Wall CR, Ley S, Wu L, Sommerville F, Brodie S, Kolbe J. Influence of Mediterranean diet on asthma symptoms, lung function, and systemic inflammation: A randomized control trial. Journal of Asthma. 2013; 50(1):75-81. • Centers for Disease Control and Prevention. CDC Vital Signs. Asthma in the US. 4 May 2011. Available at: http://www.cdc.gov/vitalsigns/asthma, assessed May 6 2013.

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