1 / 3

PATHOPHYSIOLOGY

PATHOPHYSIOLOGY. NSAID use. COX-1 inhibition. Migrate across the lipid membrane of epithelial cells. ↓prostaglandins in the gastric mucosa. Ion trapping. ↓ mucin secretion ↓HCO3 secretion ↑ HCl secretion ↓epithelial cell proliferation ↓mucosal blood flow.

ringo
Download Presentation

PATHOPHYSIOLOGY

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PATHOPHYSIOLOGY

  2. NSAID use COX-1 inhibition Migrate across the lipid membrane of epithelial cells ↓prostaglandins in the gastric mucosa Ion trapping ↓mucin secretion ↓HCO3 secretion ↑HCl secretion ↓epithelial cell proliferation ↓mucosal blood flow Direct epithelial cell toxicity Impairment of mucosal defense system

  3. Disruption of mucosal integrity NSAID use ULCERATION Inhibition of TXA2 Ulcer burrow deeper into the gastric mucosa ↓platelet aggregation Injury to the blood vessels GI BLEEDING Melena Coffe-ground emesis

More Related