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Protein turnover . Biosynthesis of a mino acids

Protein turnover . Biosynthesis of a mino acids. Léránt István. Biosynthesis of amino acids. N – NH 4 + C – glycolysis , PPP, citric acid cycle L-amino acid / D –amino acid Proteinog e n amino acids 20 (22) Essential amino acids Non essential amino acids. NADPH – L-Glutam a t e.

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Protein turnover . Biosynthesis of a mino acids

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  1. Protein turnover.Biosynthesis of amino acids Léránt István

  2. Biosynthesis of amino acids N – NH4+ C – glycolysis, PPP, citric acid cycle L-aminoacid/ D –amino acid Proteinogen amino acids 20 (22) Essential amino acids Non essential amino acids

  3. NADPH – L-Glutamate

  4. Glutaminesynthetase

  5. Synthesis of amino acids Origin of C Intermedier of glycolysis Intermedier of PPP Intermedier of citric acid cycle

  6. BIOSYNTHESIS OF AMINO ACIDS • alpha-ketoacidà alpha-amino acid Asp Ala Glu

  7. SYNTHESIS OF AMINO ACIDS Asp Ala Glu

  8. SYNTHESIS OF AMINO ACIDS • Transamination • Deamination • Decarboxylation • Glycogen-glucose PLP – Vitamin B6

  9. Glutamate SYNTHESIS OF AMINO ACIDS Glutamate-g-semialdehyde Proline Arginine Proline Arginine

  10. Glutamate SYNTHESIS OF AMINO ACIDS Glutamate-g-semialdehyde Prolin Arginin Proline Ornitine Arginine

  11. SYNTHESIS OF AMINO ACIDS Ser Glycolysis intermedier: 3-P-glycerate Transamination Dephosphorylation Ser: precursor of Gly & Cys

  12. SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys Ser Gly

  13. SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys Ser + homocysteine (Met) Cystationine Alpha-ketobutyrate + cysteine

  14. FOLIC ACID – C1 • Vitamin B9, Vitamin M • Vitamin B9 deficiency • megaloblastic anaemia • Neurological symptoms peripherial neuropathy myelopathy • vegetative disturbance • psychiatric disturbance • depression • insomnia • irritability • forgetfulness Folium Spinach 15 mg / adults Mainly - liver

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