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A. Signal Peptide. S1. S-. N 1,2. S2. DS*. N 1,2. Hs b 2. Rn b 2. z b 2B. 74. IG V-type consensus :. x. x. ^. x. ^. x. C. ^. x. W. G. N 1. N 1,2. DS*. Hs b 2. Rn b 2. 148. z b 2B. x. x. D. x. &. x. Y. x. C. ^. x. ^. x. x. ^. x. *. ^. ^.

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  1. A Signal Peptide S1 S- N1,2 S2 DS* N1,2 Hsb2 Rnb2 zb2B 74 IG V-type consensus: x x ^ x ^ x C ^ x W G N1 N1,2 DS* Hsb2 Rnb2 148 zb2B x x D x & x Y x C ^ x ^ x x ^ x * ^ ^ Transmembrane GSCS Hsb2 Rnb2 zb2B 223 x ^ x ^ C zb2 genomic structure zebrafish chromosome 15, 27.3Mb, reverse strand 3’ 5’ 1 2 3 zb2A 1 2 3 4 5 6 zb2B 2 3 5 1 4 zb2C 1 2 3 4 5 zb2D 2.65kb D y y y y y y y y -s -s -s -s IG (V-type) s- s s- s s- s s- s y y y y NH3 NH3 NH3 NH3 CO2 A B C D 15aa 45aa 38aa CO2 CO2 CO2 Transmembrane Intracytoplasmic C-terminal tail zb2B zb2C zb2D B

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