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Acid-Base Physiology by Professor Ashraf Husain

Explore the definition of pH and its significance in the body's fluid balance. Understand the normal values and measurement scale of pH, as well as the relationship between pH and H+ ion concentration. Learn about acidic, neutral, and alkaline solutions, and the properties of hydrogen ions.

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Acid-Base Physiology by Professor Ashraf Husain

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  1. ACID - BASE PHYSIOLOGY PROFESSOR. ASHRAF HUSAIN DEPT. OF PHYSIOLOGY COLLEGE OF MEDICINE KING SAUD UNIVERSITY RIYADH.

  2. Acid Base Physiology • Definition: pH is defined as potential of H+ Ion concentration in body fluid. The amount of H+ ion concentration is so low in the body hence it is expressed as –ve logarithm to base of the H+ ion concentration in mEq/lit. pH = log 1/ [H+ ] = - log [H+ ]

  3. NORMAL VALUE • Arterial blood = 7.35 – 7.45 Can be explained as follows; Normal value of H+ ion conc. is about 40nEq/lit. 40 nEq/lit = 0.00000004 Eq/lit. Therefore pH = - log [0.00000004] = 7.4

  4. pH 6.0 7.0 8.0 9.0 H+ ion in nmol/lit 1000 100 10 1.0 pH and H+ ion concentration Note : one point drop in pH results in a ten fold decrease in H+ ion conc.

  5. Scale of pH measurement • The pH scale is between 0 – 14. Zero onwards below 7 is acidic. After 7 upto 14 the solution is alkaline. At 7 (neutral e.g. water) where the amount of H+ and Hydroxyl ion are equal at 23o

  6. Since pH is inversely related to H+ ion conc. so a low pH corresponds to high H+ ion conc. (Acidic) and a high pH corresponds to low H+ ion conc. (Alkaline) Acidic Neutral Alkaline 14 7 0

  7. About H+ H+ are derived from hydrogen atoms. Hydrogen atom has proton a positive electrical charge with a negative charge electron which is revolving around it. The hydrogen ion is formed when negative ion 9electron) is lost and it contains only proton. The H+ is the smallest ionic particle, highly reactive with a very short life and unable to survive on its own.

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