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ACID - BASE PHYSIOLOGY

ACID - BASE PHYSIOLOGY. PROFESSOR. ASHRAF HUSAIN DEPT. OF PHYSIOLOGY COLLEGE OF MEDICINE KING SAUD UNIVERSITY RIYADH. Acid Base Physiology. Definition:

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ACID - BASE PHYSIOLOGY

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  1. ACID - BASE PHYSIOLOGY PROFESSOR. ASHRAF HUSAIN DEPT. OF PHYSIOLOGY COLLEGE OF MEDICINE KING SAUD UNIVERSITY RIYADH.

  2. Acid Base Physiology • Definition: pH is defined as potential of H+ Ion concentration in body fluid. The amount of H+ ion concentration is so low in the body hence it is expressed as –ve logarithm to base of the H+ ion concentration in mEq/lit. pH = log 1/ [H+ ] = - log [H+ ]

  3. NORMAL VALUE • Arterial blood = 7.35 – 7.45 Can be explained as follows; Normal value of H+ ion conc. is about 40nEq/lit. 40 nEq/lit = 0.00000004 Eq/lit. Therefore pH = - log [0.00000004] = 7.4

  4. pH 6.0 7.0 8.0 9.0 H+ ion in nmol/lit 1000 100 10 1.0 pH and H+ ion concentration Note : one point drop in pH results in a ten fold decrease in H+ ion conc.

  5. Scale of pH measurement • The pH scale is between 0 – 14. Zero onwards below 7 is acidic. After 7 upto 14 the solution is alkaline. At 7 (neutral e.g. water) where the amount of H+ and Hydroxyl ion are equal at 23o

  6. Since pH is inversely related to H+ ion conc. so a low pH corresponds to high H+ ion conc. (Acidic) and a high pH corresponds to low H+ ion conc. (Alkaline) Acidic Neutral Alkaline 14 7 0

  7. About H+ H+ are derived from hydrogen atoms. Hydrogen atom has proton a positive electrical charge with a negative charge electron which is revolving around it. The hydrogen ion is formed when negative ion 9electron) is lost and it contains only proton. The H+ is the smallest ionic particle, highly reactive with a very short life and unable to survive on its own.

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