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統合失調症の視覚ミスマッチ脳磁場の検討： MEG 研究

統合失調症の視覚ミスマッチ脳磁場の検討： MEG 研究. 前川敏彦 ，鬼塚俊明，中村一太，小田祐子 小原尚利，勝木聡美，神庭重信 九州大学大学院　医学研究院 臨床 神経 生 理学分野 精神病態 医学 分野. Memory trace hypothesis. S. S. Representation of S. (Short memory). S. S. mismatch. compare. Representation of D. D. Mismatch negativity. ( automatic process).

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統合失調症の視覚ミスマッチ脳磁場の検討： MEG 研究

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  1. 統合失調症の視覚ミスマッチ脳磁場の検討：MEG研究統合失調症の視覚ミスマッチ脳磁場の検討：MEG研究 前川敏彦，鬼塚俊明，中村一太，小田祐子 小原尚利，勝木聡美，神庭重信 九州大学大学院　医学研究院 臨床神経生理学分野 精神病態医学分野

  2. Memory trace hypothesis S S Representation of S (Short memory) S S mismatch compare Representation of D D Mismatch negativity ( automatic process)

  3. Biomarkers of Sz (前川ら：Boston CIDAR Project の中間報告，2011年　 第41回日本臨床神経生理学会　優秀ポスター賞)

  4. attention Target stimulus(10%) Deviant stimulus(10%) Standard stimulus (80%) Method • Normal Control: 9 （Male 4, 19～31（24.0） y.o.） • Schizophrenics:18 （Male15, 21～54（35.8）y.o.） • ERP was recorded by128 ch high dense EEG equipment (Netstation, Electrical Geodesics, Inc., USA) Story

  5. 1 M 21 80 18 22 47 2 F 22 400 29 27 61 3 F 26 235 15 32 40 4 M 26 555 37 42 83 5 M 27 175 18 21 50 6 M 28 85.5 30 17 68 7 M 29 262.5 10 36 46 8 M 31 1211.1 35 21 65 9 F 32 80 24 40 75 10 M 33 450 15 41 60 11 M 36 972.5 18 18 41 12 M 43 1200 23 37 9 13 M 44 500.7 9 14 25 14 M 44 390 24 35 62 15 M 46 515.9 41 38 74 16 M 48 80 16 31 49 17 M 54 1022.4 35 39 79 18 M 54 862.5 33 40 77 Schizophrenia (N=18) Pat № Sex Age BUP（Year） Drugs（CPequiv.） PANSS P N G 1 1 10 9 7 9 1 6 9 7 11 14 22 22 20 12 19 39

  6. ＮＣ ＳＺ μV -20 -10 0 10 -10 20 -5 100 100 300 300 500 500 ms ms 0 0 0 5 10 ERPs Difference waveforms Standard stim Deviant stim NC MMN2 MMN1 V-MMN(+) (n=13) Sz V-MMN(-) (n=4)

  7. MMN2 15 10 5 0 250 300 350 Amplitudes and latencies of vMMNs MMN1 μV μV ●　ＮＣ 15 ■　ＳＺ 10 5 0 ms 150 200 250 ms

  8. Summary 17 Sz data were analyzed and vMMN in 4 subjects could not detected. VMMN in all NC was clearly observed. Poor behavioral performance and decreased both P300 and vMMN in Sz group were shown. Latency of MMN1 / P300 was correlated to age, medication and PANSS negative symptom score in Sz group.

  9. Pyramidal cells: parallel orientation => spatial summation Magnetoencephalography (MEG) Neuronal currents in axons and dendrites Parallel dendrites Presynaptic Postsynaptic • Action potentials: • Fast: no/little temporal summation • Cancellation: fields diminish rapidly

  10. 306 ch MEG Deviantstim. Standard stim. 115 ms

  11. vMMF in SZ 10-22T 10-22T ms ms MMF1 MMF2 SZ (n=8): 2 female, 14-60 (mean 36.5) y.o. NC (n=12): 2 female, 22~39 (mean 30.6) y.o.

  12. Conclusion VMMF in NC group was observed at the occipital lobe, however, that in Sz group was unclear. VMMF can reflect altered visual information processing of schizophrenia.

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