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Tumor-specific chromosomal translocation

Yes. No. e.g. Osteosarcoma Chondrosarcoma Malignant fibrous histiocytome. Autologous tumor-CTL pair. cDNA library expression cloning. Novel tumor antigen. Search for HLA-anchor motif. Tumor-specific chromosomal translocation. e.g. Synovial sarcoma: SYT-SSX Ewing sarcoma: EWS-Fli1

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Tumor-specific chromosomal translocation

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  1. Yes No e.g. Osteosarcoma Chondrosarcoma Malignant fibrous histiocytome Autologous tumor-CTL pair cDNA library expression cloning Novel tumor antigen Search for HLA-anchor motif Tumor-specific chromosomal translocation e.g. Synovial sarcoma: SYT-SSX Ewing sarcoma: EWS-Fli1 Alveolar rhabdomyosarcoma: FKHR-PAX Reverse immunology Forward immunology Antigenic peptide Known tumor antigen (e.g. Cancer testis antigens)

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