The Placebo Effect

1. The Placebo Effect

2. Homeopathy In the late 1700’s a German doctor named Samuel Hahnemann invented a new form of treatment, homeopathy.

3. Made up Medicine This was about 100 years before the germ theory of disease was discovered, so we didn’t really know why people got sick or how to treat them. Treatments were just made up, and often they were worse than no treatment at all.

4. The Plague

5. The Plague • First pandemic: caused 50% drop in the population of Europe between 550 and 700. • Black death: China lost 50% of its population, Europe 1/3. This was between 1347 and 1351. • Third pandemic: Killed about 12 million people in just India and China. • From 1894 to 1901, 8,600 people died of the plague in Hong Kong, 95% of everyone infected.

6. Nutmeg for the Plague Many people in the west believed that nutmeg could cure or prevent the plague. England and Holland went to war over control of the Banda Islands, the only source for the spice.

7. Smoking! “For personal disinfections nothing enjoyed such favour as tobacco; the belief in it was widespread, and even children were made to light up a reaf in pipes. Thomas Hearnes remembers one Tom Rogers telling him that when he was a scholar at Eton in the year that the great plague raged, all the boys smoked in school by order, and that he was never whipped so much in his life as he was one morning for not smoking.” A J Bell, 1700

8. Dead Pigeons! Another “cure” for the plague was applying a dead pigeon to the sores it caused.

9. Bloodletting A common treatment in the past was bloodletting. People thought that whatever was making you sick, must be in your blood, so draining your blood would help. But this just weakens you and opens you up to an infection.

10. Harmful Medicine All medicine was made up at the time, and most of it was pretty harmful. Other examples include trepanning (drilling into the head) and ingesting mercury (a highly toxic liquid metal).

11. Law of Similars So what is homeopathy? It’s first principle is that like cures like. If you have a disease with certain symptoms, like vomiting, and you know that ipecac induces vomiting, then you assume ipecac cures the disease. In other contexts this idea is often called “sympathetic magic.”

12. Less is More The second principle was that a substance is more powerful at curing a disease when you have less of it. So you dilute your ipecac in water, and now it’s even better at curing your disease. Most contemporary homeopathic remedies are so diluted, it’s almost statistically impossible that they contain anything except water.

13. Succussion The final principle is that the remedy has to be shaken in a specific way. The bottle containing the water has to be struck ten times (not more or less) against a hard-but-not-too-hard surface. Hahnemann used a leather board filled with horse hair.

14. It Still Exists Today In France, your health insurance covers homeopathic treatment. In Britain, there are homeopathic hospitals. People in the US spend $3 billion USD a year on homeopathy.

15. Why? People think homeopathy works. Why? It’s extremely silly.

16. Why? Is it regression to the mean? Do they naturally get better after taking homeopathy, and attribute that to the medicine? Is it confirmation bias? Do they notice the times they get better after drinking the water but not the times where they don’t?

17. The placebo effect

18. Placebo ‘Placebo’ is a Latin word that means “I will please.” In a medical context, it is used to refer to pill or treatment that a doctor knows don’t do anything. The treatment pleases the patient, even though it does not actually treat his symptoms.

19. History of Placebos Common placebos are sugar pills and saltwater injections. Until the 20th Century, the placebo was a commonly used medical treatment. Patients wanted treatment, there was no treatment, so doctors gave them “dummy” pills and told them they would help.

20. Ethics of Placebos Now it’s considered unethical to lie to patients and give them fake treatment. In fact, if you pay a doctor for real treatment, and she gives you a placebo, you can sue the doctor and get your money back.

21. The Placebo in Modern Medicine But the placebo still has a role to play in modern medicine. If we are running an experiment to test a new drug, we can give participants in the control group placebos.

22. Placebo Controlled Trials A clinical trial (experiment) where the control group gets placebos is called a placebo controlled trial.

23. Best Practices Normally, we don’t use placebo controlled trials. Instead, the control group gets the best treatment there is. This is because we don’t want to know whether a new treatment is better than a placebo, we want to know if it’s better than the treatment we already have. (Also, it’s unethical not to give patients treatment when it’s available.)

24. Reasons for Placebo Controls However, when we’re testing a new treatment for a condition where there is no other treatment, or where the other treatments are ineffective for many patients, then we use placebo controls.

25. The Placebo Effect But why placebo controls instead of no treatment controls? Why do we give the control group fake pills rather than no pills at all. Because fake pills make you get better. The act of undergoing treatment– even if it is fake treatment– improves patient health.

26. The Placebo Effect In fact, the truth is even stranger than that. The anthropologist Daniel Moerman looked at several placebo controlled studies of gastric ulcer medication. A gastric ulcer is a painful sore spot in the inside of the stomach. Looking at these studies is clever, because you can count people’s ulcers.

27. More is Better What Moerman found is crazy. He found that placebo controls in experiments where the placebo was four sugar pills had fewer ulcers than placebo controls in experiments where the placebo was two sugar pills.

28. Blackwell (1972) Blackwell (1972) did a study where students were given one of two pills: a pink one and a blue one. They were told that one pill was a stimulant, which made you more alert, and the other was a sedative, that made you more sleepy.

29. Color Matters Both pills were actually placebos– just sugar pills. When Blackwell measured alertness at the end of class, he found that pink pills made you more alert than blue pills.

30. Why is Prozac Blue? Drug companies know about the effects of color on how you feel. So if you buy a stimulant, it will be red, orange, or yellow, and an anti-depressant will be blue, green, or purple.

31. Capsules Better than Pills One study of a sedative in 1970 of a sedative found that the same dosage of the drug was more effective in capsule form than in pill form. At the time capsules were new and they seemed more “sciencey” to people.

32. Injection Better than Pill Several other studies have found that saltwater injections are better than sugar pills— For headaches, blood pressure, and pain after an operation!

33. Flashy Packaging Better than Dull Studies have also found that medicine is more effective if it comes in flashy brand-name packaging, rather than generic packaging. Placebos work better in flashy packaging too.

34. Expensive Better than Cheap If you take the same pain medication– the very same pills– and charge people more for it, the medication works better. People feel less pain when they’ve paid more.

35. Fake Surgery The placebo effect isn’t just restricted to pills and injections. Sham surgery, where the doctor pretends to operate on you but does not, has been shown to reduce knee pain!

36. Surgery for Angina In the 1950’s there was a belief that you could promote artery growth (in people that needed it) by tying off a not-too-important artery in the heart and “tricking” the body into growing other arteries more. And the surgery did work, in the sense that people who underwent the surgery improved, though only a little bit.

37. More Fake Surgery But was it the procedure that helped or just the fact that they were performing surgery? In 1959, there was a placebo controlled test of this idea. The controls underwent heart surgery, but the surgeons didn’t tie off any arteries. The people who underwent the real surgery got a little better, as before. But the placebo controls improved just as much!

38. Pacemakers A Swedish study found that patients who had pacemakers installed to maintain a regular heart rate improved even if the pacemaker was not turned on.

39. Good Exercise In another study, 84 female hotel attendants were split into two groups. The experimental group was told that cleaning hotel rooms is “good exercise” and that it “satisfies the Surgeon General’s recommendations for an active lifestyle.” The other group was not told anything.

40. Good Exercise Four weeks later, both groups were measured. The group that was told that cleaning hotel rooms was “good exercise” had lost weight and had less body fat. Both groups reported that they were doing the same amount of activity!

41. Known Placebos In 1965, a study was done on “neurotic” patients (people with anxiety, stress, irrational fears, etc.). The patients were told that they were being given “a pill with no medicine in it at all.” And they showed improvement after taking it!

42. Active Placebos Sometimes placebos are pharmacologically active– they just don’t do anything anyone would want. So, for example, atropine blocks certain nerve receptors and causes dry mouth and other symptoms.

43. Active Placebos What’s the point of an active placebo? Well, they work better than regular placebos. If I pretend to be investigating pain, and give one group of people regular placebos and the other group active placebos, the active placebo group will experience less pain, on average.

44. Active Placebos The explanation for this phenomenon is something like this: When people take the active placebos, they experience the side effects. This makes them believe that the drugs are powerful and really work, and the power of their belief then influences what they experience.

45. Antidepressants Recently, it has been argued by a number of scientists that antidepressant drugs, especially SSRIs, are just active placebos. This is pretty serious, if true. 1 in 10 Americans are on antidepressants, and they have serious side effects (insomnia, sexual dysfunction, appetite loss), can cause sever withdrawal, and are very expensive.

46. Meta-Analysis A meta-analysis is a study that looks at lots of clinical trials and uses data from all of them. Irving Kirsch, a psychologist, conducted a meta-analysis of all the drug-company sponsored antidepressant trials sent to the US Food and Drug Administration. (The FDA approves the use of drugs, when companies can show they work.)

47. Placebos vs. Antidepressants Kirsch found that placebos are 82% as good as antidepressants. That means that if you take a placebo, you’ll feel about 82% better than someone who takes the real thing. And the difference is small. What’s the extra 18% benefit of the real thing? 1.8 points on the 54 point scale doctors use to measure the severity of depression. (Sleeping better: 6 points, less fidgety: 2 points)

48. Antidepressants as Active Placebos That number goes to 100%, he argues, when active placebos are compared with antidepressants. That is, active placebos cause the exact same improvement in depression symptoms as expensive, habit-forming, government approved, antidepressant drugs. It’s depressing!

49. Bad Medicine So why do so many people turn to medicine that has no scientific basis, like homeopathy? There are some reasons we’ve discussed before. One is the regression fallacy: they get treatment when they’re feeling worst, they “regress to the mean,” and they attribute their improvement to the treatment.

50. Bad Medicine So why do so many people turn to medicine that has no scientific basis, like homeopathy? Another reason is confirmation bias. They notice the times when they get the treatment and later feel better, but they don’t notice the times when the treatment does not work.