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eCuration : speed curating with PubTator

Zhiyong Lu, Earl S tadtman Investigator National Center for Biotechnology Information (NCBI) National Library of Medicine (NLM) National Institutes of Health (NIH). eCuration : speed curating with PubTator. eCuration (computer-assisted biocuration) is necessary.

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eCuration : speed curating with PubTator

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  1. Zhiyong Lu, Earl Stadtman Investigator National Center for Biotechnology Information (NCBI) National Library of Medicine (NLM) National Institutes of Health (NIH) eCuration: speed curating with PubTator

  2. eCuration (computer-assisted biocuration) is necessary

  3. Most searched topics in PubMed Bibliographic Non-bibliographic

  4. Key biological entities

  5. Our NER Tools • Freely available & open source • High Performance • DNorm: Best in 2013 ShARe/CLEF shared task on Disease Normalization • tmChem: Best in 2013 BioCreative IV Chemical Entity Mention task • GenNorm: Best in 2010 BioCreative III Gene Normalization Task • BioC format compatible for improved interoperability All numbers are F1 scores

  6. Our tmTools are publicly available • DNorm: www.ncbi.nlm.nih.gov/CBBresearch/Lu/Demo/Dnorm/ • tmVar: www.ncbi.nlm.nih.gov/CBBresearch/Lu/pub/tmVar/ • SR4GN: www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/SR4GN/ • GenNorm: http://ikmbio.csie.ncku.edu.tw/GN/ • tmChem: http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/Demo/tmChem/ To make it easy for biocurators, we have already applied all these tools to PubMed abstracts and store results in our Web-based annotation tool – PubTator!

  7. PubTator Intro/Highlights • Web-based; no installation required; in sync with PubMed • One-stop curation service from literature search to annotation • Curator friendly (PubMed-like) interface; easy to use • Integrates competition-winning text-mining tools for automatic pre-annotations • Easy to adapt and customizeto different curation tasks Wei, Kao, & Lu: PubTator: a Web-based text-mining tool for assisting biocuration, to appear in Nucleic Acids Research, 2013

  8. PubTator’s Curation Interface Document triage Bio-concept annotation Bio-relation annotation

  9. BioCreativeChallenge (2003 – ) www.biocreative.org

  10. PubTator evaluation • Task: manually annotating genes in 50 abstracts • Experimental settings (25 abstracts each) • PubMed + spreadsheet (baseline) • PubTator + computer-generated gene results • Results: 40% decease in curation time & slightly higher accuracy Wei, Harris, … Lu. Accelerating literature curation with text mining tools: a case study of using PubTator to curate genes in PubMed abstracts. Database, 2012; bas041

  11. Top rated by biocurators Arighi, et al., An overview of the BioCreative 2012 Workshop Track III: interactive text mining task. Database, 2013. bas056

  12. Successful applications of PubTator “PubTator substantially reduces the manual data input involved, reflected in both time-savings and reduction in physical fatigue of keyboard typing.” – Mindy C.

  13. Discussions • eCuration: computer-assisted curation can improve productivity • Future directions • Working with ontologies • Working with full-text • What would you do with PubTator?

  14. Acknowledgments • My Team • Rezarta Dogan • Bethany Harris • RituKhare • AurelieNeveol • Yuqing Mao • Robert Leaman • Jiao Li • Chih-Hsuan Wei • BioCreative • Lynette Hirschman, MITRE • Kevin Cohen, U of Colorado • Alfonso Valencia; Martin Krallinger, CNIO • Cecilia Arighi, Cathy Wu, U of Delaware • Carolyn Mattingly; Tom Wiegers, NCSU Supported by NIH Intramural Research Program, National Library of Medicine.

  15. Pacific Symposium on Biocomputing (PSB) 2015 January 4 – 8, 2015 The Big Island of Hawaii Crowdsourcing and Mining Crowd Data Crowdsourcing techniques microtask environments games with a purpose workflow sequestration Crowd data human genomics sequence data electronic health records social media data Robert Leaman and Zhiyong Lu, NCBI/NLM/NIH Ben Good and Andrew Su, Scripps Research Institute

  16. Questions? Thank you! zhiyong.lu@nih.gov

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