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Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues.

Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues. Rolling. Activation. Adhesion. CD11a/CD18. Transmigration. CD11b/CD18. Selectins. Chemokines:. ICAM-1. Chemotaxins:. MCP-1. C5a. chemokines. Figure 2.

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Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues.

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  1. Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues. Rolling Activation Adhesion CD11a/CD18 Transmigration CD11b/CD18 Selectins Chemokines: ICAM-1 Chemotaxins: MCP-1 C5a chemokines

  2. Figure 2. Northern blot showing glomerular expression of MCP-1 mRNA correlated with monocyte infiltration

  3. Figure 3. Schematic diagram showing regulation of the effects of IL‑1b. Biological effects of IL‑1 are tightly regulated, in part by its endogenous receptor antagonist (IL‑1ra), as well as by expression of IL‑1 type II receptor (IL‑1RtII). IL‑1RtII (68 kD) binds to IL‑1b with high affinity (lower affinity for IL‑1a and IL‑1ra) without signal transduction. The extracellular domain of IL‑1RtII can also be released as a soluble receptor selective for IL‑1b. Hence, IL‑1RtII is also know as a decoy receptor that may reduce the effect of IL‑1b.

  4. Figure 4. Northern blot showing synthesis of IL-1 decoy receptor in the glomeruli of IL-4 treated rats

  5. 8 p=0.02 6 Control Cells/ glomerular section (gs) 4 IL-4 p=0.002 2 0 activated Mf all Mf Figure 5. Effect of IL-4 on glomerular macrophages (Mf)

  6. Figure 6. Blocking TNF-a prevented crescentic glomerulonephritis 50 40 30 Crescents (%) 20 10 0 sTNFR Control

  7. Figure 7. Delayed treatment with rolipramreduces urinary TNF-a 500 (pg/17h) p = 0.05 400 a 300 200 Urinary TNF- 100 0 vehicle rolipram

  8. 40 p < 0.05 30 (quadrants/50 gs) Crescents 20 10 0 vehicle rolipram Figure 8. Delayed treatment with rolipram reduces glomerular crescents

  9. Figure 9. Short term treatment (day 0-7) with IL-4reduction of renal injury at day 28 p<0.01 p<0.01 100 4 75 3 Crescents (%) Tubular damage 50 score 2 25 1 0 0 Control IL-4 IL-4 Control

  10. Figure 10. IL-11 inactivated glomerular macrophages All Mf Activated Mf NS *P<0.05 2.0 50 40 1.5 ED-3+ Mf/gcs 30 ED-1+ Mf/gs 1.0 20 0.5 10 0.0 0 Control IL-11 Control IL-11

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