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NIGERIA

NIGERIA. COUNTRY PRESENTATION. By: Drs. Uzono Levi G and Adegboyega Adewumi. 4 th September 2004. REMINDER – The main issues. Which ARVs are available in your Country Do you have treatment guidelines What information is available to -Health professionals -The Public

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NIGERIA

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  1. NIGERIA COUNTRY PRESENTATION By: Drs. Uzono Levi G and Adegboyega Adewumi 4th September 2004

  2. REMINDER – The main issues • Which ARVs are available in your Country • Do you have treatment guidelines • What information is available to -Health professionals -The Public • Is there any safety Monitoring in your Country

  3. Presentation Outline • About Nigeria • Epidemiology of HIV/AIDS • The National ART Programme • The main Issues • Conclusion

  4. Nigeria located in Western Africa, bordering the Gulf of Guinea, between Benin and Cameroon Important Statistics • Population: 123.9m (1999) • Life Expectancy at Birth (LEB): 52years • Urban: Rural Ratio: 50:50 (approx) • Adult Literacy Level: 55.6% • External Debt: US$ 31.6 billion • Poverty Level: 65% live below Poverty level • HIV Prevalence: 5.0% (end of 2003) • Estimated HIV Burden: 3.47million (2001) • Estimated AIDS Burden: 1.2million (2001)

  5. Epidemiology of HIV/AIDS • Since 1986 when the first AIDS case was detected in Nigeria, the epidemic has rapidly grown. • The adult HIV prevalence has increased from 1.8% in 1991 to 4.5% in 1996 to 5.8% in 2001 and finally 5.0% at the end of 2003. • Estimates using the 2001 HIV seroprevalence sentinel survey of women attending ante-natal clinics indicate that the more than 3.5 million Nigerians were infected with the virus in 2002.

  6. The National ART Programme • In 2001 the Federal Government of Nigeria adopted a policy to provide antiretroviral treatment to people living with HIV/AIDS in the country. • By the middle of 2004, approximately 13,500 people were receiving ARV treatment from these centres and many more were on waiting lists. • Implementation of the program began in 2002 with 25 centres selected to provide ART in various parts of the country.

  7. HIV Prevalence per State end of 2003 and States with ARV Centers Sokoto State 4.5% *Sokoto *Katsina Yobe State *Birnin Kebbi Katsina State Jigawa State Borno State *Gusau 3.3% *Kano 2.0% 3.2% Zamfara State 2.5% Kano State 3.3% Kebbi State *Dutse *Damaturu *Maiduguri 4.1% 2.5% Bauchi State Gombe State 4.3% Niger State *Kaduna 6.8% Kaduna State *Bauchi *Gombe Adamawa State Kwara State 7.0% *Jos *Minna 6.0% 7.6% 2.7% 6.3% *Jalingo FCT ** Plateau State < 5% NasarawaState *Yola Oyo State *Ilorin 8.4% ** 6.5% 3.9% *Lokoja *Lafia Taraba State 5 - 7% *Ibadan *Osogbo Ekiti State 5.7% 2.0% 1.2% Kogi State *Ado Ekiti Osun State *Makurdi 6.0% *Abeokuta 9.3% *Akure 1.5% Edo State Benue State 7 -12% + 2.2% Ogun State Ondo State 4.9% *Ikeja 4.3% 3.3% Enugu State 4.7% *Benin City 7.2% Anambra State Lagos State * *Asaba *Enugu ARV Centers *Awka Ebonyi State 3.1% 5.0% IAbia State 12% Imo State Cross River State Delta State 3.7% Lagos Has 3 ARV Centers *Owerri *Yenagoa Rivers State 7.2% *Calabar * 4.0% Bayelsa State 6.6% *Uyo *Port Harcourt Akwa Ibom State Abuja Has 7 ARV Centers ** MO-ARVS NASCP – FMOH 15th June 2004

  8. Treatment Needs The epidemic has extended beyond the commonly classified high-risk groups to the general population. As at the end of 2001, at least three and a half million people are living with HIV/AIDS, which is expected to rise to well over four million in 2008. Cumulative deaths by 2008 are predicted to be between 3.6 to 4.2 million. Out of this, between 300,000 to 700,000 people are in urgent need of treatment.

  9. ?Which ARVs are available in your Country

  10. Currently registered/listed in Nigeria either as single products or in fixed dose combinations we have 6 Nucleoside Reverse Transcriptase Inhibitors (NRTIs), • 2 Non Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and 5 Protease Inhibitors (PIs)

  11. ARVs currently Registered with National Agency for Food and Drug Administration and Control (NAFDAC)

  12. ?Do You have Treatment Guidelines Yes! GUIDELINES FOR THE USE OF ANTIRETROVIRAL (ARV) DRUGS IN NIGERIA FEDRAL MINISTRY OF HEALTH ABUJA, NIGERIA JULY 2001 Draft GUIDELINES FOR THE USE OF ANTIRETROVIRAL (ARV) DRUGS IN NIGERIA FEDERAL MINITRY OF HEALTHABUJA – NIGERIA AUGUST 2004

  13. Contents • 1.0 Introduction . • 2.0 Virology and Pathogenesis of HIV • 3.0 Diagnoses of HIV infection and AIDS • 4.0 Antiretroviral therapy (ART) • i. Classes of ARV Drugs - Available ARV drugs • ii. Criteria for initiation of therapy • iii. Recommended and alternative regimen of ART • iv. Adverse drug reactions and Interactions • v. When to switch ART • vi. When to stop ART • 5.0 Follow-up and Monitoring patients on ART • 6.0 Key issues in ART • i. Adherence • ii. Immune Reconstitution Syndrome • iii. Treatment experienced patients • Indications for Referral • 7.0 Prevention of Mother to Child Transmission • 8.0 Post Exposure Prophylaxis and Universal Safety Precautions • 9.0 Management of TB and Other Opportunistic Infections • 10.0 Supportive management • i.Nutrition • ii. Psychosocial Support • iii. Palliative Care

  14. Treatment Protocol Recommended and alternative regimens for adults and children • First line regimen for adultsd4T / 3TC / NVP • Alternative first line drugs for special category of adults: • ü Pregnant women or women of childbearing age • ZDV / 3TC / NVP • ü Adults with tuberculosis co-infection (that require Rifampicin containing regimen for TB treatment) • d4T / 3TC / EFV First line regimen for childrend4T / 3TC / NVP Alternative first line drugs for special category of children: Children with tuberculosis co-infection (that require Rifampicin containing regimen for TB treatment) d4T / 3TC / EFV (not recommended for children below 3 years)

  15. ?What information is available to -Health Professionals-The Public ?

  16. ?Is there any Safety Monitoring in your Country • What we have is post marketing surveillance, which is the responsibility of NAFDAC • Address the issues of counterfeit drugs and other regulatory products through • -Public Enlightenment Campaigns • -monitoring of Good Manufacturing Practices, -beefing up surveillance at the ports • -Mopping-up fake / counterfeit drugs and other regulated products

  17. The Future ? The launching of Pharmacovigilance on the 9th of September will initiate drug safety monitoring with special emphasis on ADRs

  18. Conclusion -Pharmacovigilance in Nigeria We are compiling Sample reports to get fully registered with the Uppsala Monitoring Center Draft Guidelines for Pharmacovigilance has been developed Draft case reporting forms have been developed On the 9th of September the official launching will take place

  19. Ke a leboga Thank You

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