1 / 3

Rural clinical cohort HIV-infected individuals + HIV-negative controls

Septicaemia in a population-based clinical cohort in rural Uganda, 1996 - 2007: Incidence, aetiology, antimicrobial drug resistance and impact of antiretroviral therapy. Rural clinical cohort HIV-infected individuals + HIV-negative controls Incidence of septicaemia (per 1000 pyrs)

sandro
Download Presentation

Rural clinical cohort HIV-infected individuals + HIV-negative controls

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Septicaemia in a population-based clinical cohort in rural Uganda, 1996 - 2007: Incidence, aetiology, antimicrobial drug resistance and impact of antiretroviral therapy Rural clinical cohort HIV-infected individuals + HIV-negative controls Incidence of septicaemia (per 1000 pyrs) 2.6 (HIV-uninfected) 67.1 (HIV-infected not on ART) 121.4 (HIV-infected on ART in 1st year) 37.4 (HIV-infected on ART after 1st year) MRC

  2. AetiologyS. pneumoniae (42.8%), NT salmonella (26.4%), E.coli (5.7%) Incidence per 1000 pyrs S. pneumoniae 1.5 in HIV-uninfected 28.4 in HIV-infected not on ART 29.6 in HIV-infected on ART 19.8 in males vs 7.8 in females NT Salmonella 0.4 in HIV-uninfected 20.7 in HIV-infected not on ART 7.4 in HIV-infected on ART MRC

  3. Antimicrobial resistance • S. pneumoniae and NTS resistant to common and cheap antibiotics • S. pneumoniae highly sensitive to ceftriaxone and erythromycin • NTS highly sensitive to ciprofloxacin Policy implications • In Uganda, use ciprofloxacin with ceftriaxone or erythromycin for suspected septicaemia • Pattern of pathogens and their antibiotic resistance should be monitored • Laboratory surveillance systems with good blood culture facilities essential MRC

More Related