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Medical Microbiology

Medical Microbiology. Chapter 49 Mechanisms of Viral Pathogenesis. Viral Pathogenesis. Viral replication review Most viruses exhibit a very specific tissue tropism Cold viruses, influenza, hepatitis Some do not: Herpes Simplex Virus – type 1. Viral Pathogenesis.

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Medical Microbiology

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  1. Medical Microbiology Chapter 49 Mechanisms of Viral Pathogenesis

  2. Viral Pathogenesis • Viral replication review • Most viruses exhibit a very specific tissue tropism • Cold viruses, influenza, hepatitis • Some do not: Herpes Simplex Virus – type 1

  3. Viral Pathogenesis • The effects of a virus on a cell: • Failed infection (abortive infection) • Cell death (lytic infection) • Viral proteins lyse the host cell • Formation of sycytia • Induction of apoptosis

  4. Viral Pathogenesis • Infection without cell death (persistant infection) • Chronic – new viruses produced • Latent – infection without new virion production • Transforming – cells divide rapidly

  5. Progression of Viral Disease • Steps – Box 49-2

  6. Viral Disease • Different types of viral infections – Figure 49-3

  7. Epidemiology • Important notes: • Naked viruses resist drying • Respiratory • Fecal-oral • Fomites • Enveloped viruses must remain wet for infection • Body fluids • Injection • transplants

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