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Genomic Evaluations in the United States

Genomic Evaluations in the United States. Organizational roles. Council on Dairy Cattle Breeding (CDCB) responsible for receiving data, computing, and delivering U.S. genetic evaluations for dairy cattle

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Genomic Evaluations in the United States

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  1. GenomicEvaluationsin the United States

  2. Organizational roles • Council on Dairy Cattle Breeding (CDCB)responsible for receiving data, computing, and delivering U.S. genetic evaluations for dairy cattle • Animal Improvement Programs Laboratory (AIPL)responsible for research and development to improve the evaluation system • CDCB and USDA employees co-located in Beltsville

  3. Funding • CDCB evaluation calculation and dissemination funded by fee system • Based on animals genotyped • About 80% of revenue from bulls • Higher fees for herds that contribute less information • AIPL research on evaluation methodology funded by U.S. Federal government

  4. Information sources for evaluations • Traditional evaluations of genotyped bulls and cows used to estimate SNP effects • Combined final evaluation • Sum of SNP effects for an animal’s alleles • Polygenetic effect • Traditional evaluation • Pedigree data used and validated by genotypes

  5. Evaluation flow • Animal nominated for genomic evaluation by breed association or AI organization • Hair or other DNA source sent to genotyping lab • DNA extracted and placed on chip for 3-day genotyping process • Genotypes sent from genotyping lab to AIPL for accuracy review   

  6. Evaluation flow(continued)  • Genotype calls modified as necessary • Genotypes loaded into database • Nominators receive reports of parentage and other conflicts • Pedigree or animal assignments corrected • Genotypes extracted and imputed to 45K • SNP effects estimated     

  7. Evaluation flow(continued)  • Final evaluations calculated • Evaluations released to dairy industry • Download from CDCB FTP site with separate files for each nominator • Monthly release for new animals • All genomic evaluations updated 3 times each year with traditional evaluations 

  8. U.S. genomic evaluation team

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