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Making my first reagent during the STEM Engines 2008 Summer Research.

Alicia A. Gilmore (Prof. M.A. Jones) www.chem.ilstu.edu/stem Testing the Effects of Metalloporphyrins on Leishmania tarentolae.

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Making my first reagent during the STEM Engines 2008 Summer Research.

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  1. Alicia A. Gilmore (Prof. M.A. Jones)www.chem.ilstu.edu/stemTesting the Effects of Metalloporphyrins on Leishmania tarentolae “Researching this summer in the STEM Engines program was a very good experience for me. It was not only interesting, it was also very insightful in what it had to teach me about how research works. I enjoyed research very much and plan on doing this again in my college career.”- A. Gilmore At right: Growth pattern comparisons of Leishmania tarentolae with addition of Sn-P IX or Zn-P IX This project included testing the effects of selected metalloporphyrins on the growth and viability of Leishmania tarentolae. The Leishmania parasite causes Leishmaniasis, a group of diseases that affect the skin and organs. It is a growing epidemic infecting millions every year. The Leishmania parasite can not produce its own heme, an iron containing porphyrin. Thus, metalloporphyrins were tested to see what effects changing the metal ion in the complex had on the Leishmania. The cells were treated with 10uM of the metalloporphyrins and analyzed for growth and viability using the MTT assay. In addition to Zn-protoporphyrin-IX, Sn-protoporphyrin-IX and Ag-mesoporphyrin-IX were tested for their toxicity. Zn-protoporphyrin-IX had the greatest inhibitory effect on the cell cultures. The Zn- protoporphyrin-IX could be tested in human tissue cultures in the future. Making my first reagent during the STEM Engines 2008 Summer Research.

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