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BIO wulf

BIO wulf. BIO wulf. R A D I O L O G Y. BIOwulf Radiology. BIO wulf. Technologies. Genomics. Radiology. Radiology. BIO wulf. BIO wulf. Agenda. R A D I O L O G Y. Company Overview Analytics Current Projects Future Applications. BIO wulf. Company Overview. BIO wulf.

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BIO wulf

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  1. BIOwulf BIOwulf R A D I O L O G Y BIOwulf Radiology BIOwulf Technologies Genomics Radiology Radiology

  2. BIOwulf BIOwulf Agenda R A D I O L O G Y • Company Overview • Analytics • Current Projects • Future Applications

  3. BIOwulf Company Overview BIOwulf R A D I O L O G Y People Technology Applications Intellectual Property

  4. BIOwulf • Washington University • St. Louis University • Chief of Diagnostic Radiology • 25 years of practice Company Overview BIOwulf People R A D I O L O G Y Garry Carls,M.D., M.B.A. Garry Carls has Radiology experience in both the academic and private practice arenas.

  5. BIOwulf • University of Pittsburgh • Purdue University • 20+ Medical and Technical journals • NCI – Ovarian cancer detection Company Overview BIOwulf People R A D I O L O G Y Hong Zhang,Ph.D. While attending college, Hong Zhang won a national math competition in China.

  6. BIOwulf • Academy of Sciences in USSR • Institute of Electrical Communications • 150+ published papers • Pattern recognition Company Overview BIOwulf People R A D I O L O G Y Shelia Guberman, Ph.D. Shelia Guberman authored the first applied pattern recognition program.

  7. BIOwulf • Illinois State University • Merck Pharmaceuticals • Analytical biochemistry • Finance and marketing Company Overview BIOwulf People R A D I O L O G Y Tony Barnes,Ph.D., M.B.A. PHOTO Tony Barnes holds a Ph.D. in analytical biochemistry from the University of Illinois.

  8. BIOwulf Company Overview BIOwulf People People R A D I O L O G Y Management Team Peter Farley, M.D., MBA Tony Barnes, Ph.D., MBA Garry Carls, M.D., MBA Russ Clark, JD Katherine DeYoung, Ph.D. Isabelle Guyon, Ph.D. Ramananda Madyastha, M.D., Ph.D Mary Napier, MS Tim O’Hayer Trey Rossiter, MBA Michael Stern, MBA

  9. BIOwulf Company Overview BIOwulf People People R A D I O L O G Y Mathematical Team Peter Bartlett, Ph.D. Asa Ben-Hur, Ph.D. Olivier Bousquet, Ph.D. Olivier Chappelle, Ph.D. Nello Christianini, Ph.D. Rene Doursat, Ph.D. Andre Elisseeff, Ph.D. Shelia Guberman, Ph.D. Isabelle Guyon, Ph.D. Bernhard Schoelkopf, Ph.D. Vladimir Vapnik, Ph.D. Jason Weston, Ph.D. Hong Zhang, Ph.D.

  10. BIOwulf Company Overview BIOwulf People People R A D I O L O G Y Science Advisory Board Vladimir N. Vapnik, Ph.D. (Co-Chairman) AT&T Labs - Research Herbert A. Fritsche, Jr., Ph.D. (Co-Chairman) University of Texas M.D. Anderson Cancer Center Daniel W. Chan, Ph.D. John Hopkins University School of Medicine The John Hopkins Hospital Alexey Chervonenkis, Ph.D. Institute of Control Sciences, Russian Academy of Sciences Jeffery Cossman, M.D. Georgetown University Medical Center Alex Gammerman, Ph.D. Royal Holloway College, University of London

  11. BIOwulf Company Overview BIOwulf People People R A D I O L O G Y Science Advisory Board Federico Girosi, PH.D. Harvard University Kelvin G. Lynn, Ph.D. Boeing Chair, Washington State University Tomaso A. Poggio, Ph.D. Massachusetts Institute of Technology Thomas A. Stamey, M.D. Stanford University School of Medicine Morton Schwartz, Ph.D. Memorial Sloan-Kettering Cancer Center John F.R. Robertson, M.D. The University of Nottingham

  12. BIOwulf Company Overview BIOwulf People People R A D I O L O G Y Collaborations Johns Hopkins University M.D. Anderson Cancer Center Stanford University University of Nottingham University of Cincinnati

  13. BIOwulf Company Overview BIOwulf Technology Technology R A D I O L O G Y Supervised machine learning techniques including Support Vector Machines.

  14. BIOwulf Life Sciences Telecom Internet Financial QualityManagement Military Seismic Geological Imaging Company Overview BIOwulf Applications R A D I O L O G Y

  15. BIOwulf Company Overview BIOwulf Intellectual Property R A D I O L O G Y Patents Issued & Pending 09/303,386 Pre-Processing and Post Processing for Enhancing Knowledge Discovery Using Support Vector Machines. 09/303,387 Enhancing Knowledge Discovery Using Multiple Support Vector Machines. 09/303,389 Optimal Categorization of a Continuous Variable. 09/305,345 Enhancing Knowledge Discovery Using Support Vector Machines in a Distributed Network Environment. PCT/US99/09666 Pre-processing and Post Processing for Enhancing Knowledge Discovery Using Support Vector Machines. 09/568,301 Enhancing Knowledge Discovery From Multiple Data Sets Using Multiple Support Vector Machines. 09/578,011 Enhancing Knowledge Discovery from Multiple Datasets using Multiple Support Vector Machines.

  16. BIOwulf Company Overview BIOwulf Intellectual Property R A D I O L O G Y Patents Issued & Pending 60/161,806 Applications of SVMs in Genomics and Cancer Research. PCT/US00/14326 Enhancing Knowledge Discovery from Multiple Datasets using Multiple Support Vector Machines. 09/633,850 Methods of Identifying Patterns in Biological Systems and Methods of Uses Thereof. 09/633,616 Enhancing Biological Knowledge Discovery Using Multiple Support Vector Machines. 09/633,615 Methods of Identifying Biological Patterns Using Optimal Categorization of a continuous variable. 09/633,627 Methods of Identifying Biological Patterns in a Distributed Network and Multiple Data sets. 60/168,703 Applications of SVMs in Genomics and Cancer Research ALL/AML Leukemia Classifier.

  17. BIOwulf Company Overview BIOwulf Intellectual Property R A D I O L O G Y Patents Issued & Pending 60/184,596 Applications of SVMs in Genomics and Cancer Research (Colon Cancer). 60/191,219 Gene Selection for Cancer Classification Using Support Vector Machines. 60/207,026 Applications of SVMs in Genomics and Cancer Research ALL/AML Leukemia Classifier.

  18. BIOwulf Analytics BIOwulf R A D I O L O G Y

  19. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Advantages of Machine Learning • Data driven, automated learning • May handle highly complex systems • Can detect subtle patterns

  20. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Inversion of Convoluted Data

  21. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Methodologies Holistic Analytic

  22. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Holistic Methods

  23. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Analytic Methods Preprocessing Learning Machine

  24. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Analytic Tools Feature Extraction Learning Machines FFT Wavelet Perceptron LDA PCA Radon ANN SVM Kernel PCA HMM RKHS … Hough Splines …

  25. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Designer Math: An Evolutional Process • Custom designed mathematical techniques focused on specific real problems • Cross-training between mathematicians and • biologists/physicians/other experts • Applications of cutting edge mathematical theories • Integration of expert domain knowledge

  26. BIOwulf Analytics BIOwulf Machine Learning R A D I O L O G Y Domain Specific Solutions Problem Solving Cycle Data Domain Expertise Theoretical Foundation Algorithm Development Fine Tune To Problem BIOwulf will extract pertinent knowledge by using the raw data, incorporating domain specific expertise in biology, applying leading mathematical theory, developing customized algorithms, and including the outcome feedback to fine tune predictive solutions.

  27. BIOwulf Analytics BIOwulf Imaging R A D I O L O G Y Example: Imaging • Combination of radiology, machine learning, image processing, and mathematical analysis • Effective algorithm based on radiologists’ knowledge • Customized SVM for “transduction”

  28. BIOwulf Analytics BIOwulf Imaging R A D I O L O G Y Example: Imaging • Modified SVM with variable input size and adjustable regularizations • Innovative feature extractions (e.g., Radon transform) • Unparalleled accuracy in initial calcification detection system

  29. BIOwulf Analytics BIOwulf Imaging R A D I O L O G Y Imaging Related IP • A holistic method for computer aided automatic detection of micro calcification clusters in mammogram images. • Support vector machine based system for multi-spectra image analyses. • Mammogram feature selection based on Radon transform. • Combining image data with clinical information using kernel techniques for comprehensive diagnostic systems. • An efficient automatic border detection method for mammogram images. • Orientation detection based on orthogonal group representation and support vector machine. • Multi-scale histogram method for preprocessing of image data in support vector based classification systems. • A transduction method for variable point evaluations in image analyses. • Asymmetry detection using graph theoretic models in mammogram images. • Accurate calculations of geometric invariants in parameters from planar and volumetric image data.

  30. BIOwulf Current Project(s) BIOwulf R A D I O L O G Y

  31. BIOwulf Current Project(s) BIOwulf R A D I O L O G Y • Mammography • Calcification • detection • Mass detection • Structure distortion • detection

  32. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Breast Cancer • 700,000 deaths in the world in 2000 • 41,000 deaths in USA in 2000 • 1 in 8 probability that a woman will develop breast cancer in her lifetime • 1 in 30 probability she will die as a result

  33. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Scope of the Problem • False negative rate as high as 25% • Double reading improves diagnosis by 15% • 70% of lesions are benign at biopsy • Up to 75% of cancers visible in retrospect • Sensitivity of current CAD programs 85%, but specificity is less than 40%

  34. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Computer Aided Diagnosis • Consistency: • Reduce missed interpretations due to fatigue and distraction • Improved Confidence: An additional diagnostic tool • Enhanced Performance: Draws attention to suspicious microcalcifications, masses, and architectural distortion

  35. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Market • 44.5 million mammograms in USA in 2000 • 6% increase compared to 1999 • CAD in its infancy • 10,000 registered mammography sites in US • 9% currently use CAD • 8% indicate intent to purchase CAD in next 3 years

  36. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Mass detection subsystem Calcification detection subsystem Structure distortion detection subsystem Asymmetry detection Calcification segmentation Speculation detector Mass segmentation Local SVM analyzer Feature extraction Feature extraction Feature extraction SVM classifier Global SVM classifier SVM classifier Overall SVM analyzer

  37. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  38. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  39. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Calcification Detection MammogramImages CalcificationSegmentation Local SVM Analyzer Feature Extraction Global SVM Classifier Overall SVM Analyzer

  40. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Calcification Detection

  41. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Feature Extraction

  42. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Preliminary Statistics

  43. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  44. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  45. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mass Detection MammogramImages AsymmetryDetection Mass Segmentation Feature Extraction SVM Classifier Overall SVM Analyzer

  46. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  47. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  48. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Structure Distortion Detection MammogramImages SpiculationDetector FeatureExtraction SVM Classifier Overall SVM Analyzer

  49. BIOwulf Current Project(s) BIOwulf Mammography R A D I O L O G Y Mammogram Images Calcification DetectionSubsystem Mass Detection Subsystem Structure DistortionDetection Subsystem Overall SVM Analyzer

  50. BIOwulf Future Applications BIOwulf R A D I O L O G Y Computerized Axial Tomography (CAT) • Computer Aided Diagnosis • Tumor Volume Analysis • Diagnosis/Prognosis • Response to Therapy Magnetic Resonance Imaging (MRI) Molecular Imaging • Functional Life Science Imaging Science

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