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Institute for Systems Biology Moritz Lab

Institute for Systems Biology Moritz Lab. Jeff Mangalin Nano 250 Spring 2013. Outline. Who, what & where of ISB. Mortiz Lab What is HPLC ? Goals for the quarter. Institute for Systems Biology. Non-Profit Research Institution Founded in 2000 Located in Seattle’s SLU

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Institute for Systems Biology Moritz Lab

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  1. Institute for Systems BiologyMoritz Lab Jeff Mangalin Nano 250 Spring 2013

  2. Outline Who, what & where of ISB. Mortiz Lab What is HPLC? Goals for the quarter.

  3. Institute for Systems Biology Non-Profit Research Institution Founded in 2000 Located in Seattle’s SLU Four Areas of Focus P4 Medicine predictive, preventive, personalized and participatory medicine. Global Health Sustainable Environment Education & Outreach

  4. Dr. Leroy Hood Education M.D John Hopkins Ph.D. Cal Tech Focus on Biotechnology, & Genomics Awards 2011 National Medal of Science 2011 Russ Prize for automating DNA sequencing 2010 Kistler Award and the list goes on… • Inventions • Protein Sequencer • Protein Synthesizer • DNA Synthesizer • Automated DNA Sequencer • Ink-Jet DNA Synthesizer

  5. Moritz Lab Proteomics Core Facility Fee for Service Facility Over 20 Mass Spectrometers Services Protein Identification & Biomarker Discovery Characterization of post-translational modifications Quantitative Top-Down Proteomics using 2-D gels Quantitative Bottom-Up Proteomics using LC-MS

  6. High Performance Liquid Chromatography

  7. EksigentcHiPLC System Docking station Up to 3 microfluidic chips

  8. Results .

  9. Goal for the Quarter Compare the performance of traditional house packed columns vs the state-of-the-art cHiP LC system. Looking for changes in sensitivity Reproducibility of results I predict that the cHiP LC system will be better.

  10. Summary Who, what & where of ISB. Mortiz Lab What is HPLC? Goals for the quarter.

  11. References http://corefacilities.systemsbiology.net/proteomics/images/Header.jpg http://www.geekwire.com/wp-content/uploads/2011/05/isb2.jpg http://www.protein.iastate.edu/images/hplc.jpg http://www.eksigent.com/images/Fixed%20size/Prod-180x224-40x40/eksigent-cHiPLC-System.jpg

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