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NAC Nucleic Acid Center. Funding 2001-2011 from the Danish National Research Foundation. Department of Physics, Chemistry and Pharmacy & Department of Biochemistry and Molecular Biology University of Southern Denmark. NAC organisation. Biomolecular NMR Spectroscopy RNA Molecular Biology
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NACNucleic Acid Center Funding 2001-2011 from the Danish National Research Foundation Department of Physics, Chemistry and Pharmacy & Department of Biochemistry and Molecular Biology University of Southern Denmark
NAC organisation Biomolecular NMR Spectroscopy RNA Molecular Biology Michael Petersen Stephen Douthwaite Birte Vester Synthetic Bioorganic Chemistry – DNA/LNA Chemistry Jesper Wengel Poul Nielsen Erik Bjerregaard Pedersen Stefan Vogel
NAC – key numbers 2001-2011 a) 65 M DKK funding from DNRF + 115 M DKK other external funding + SDU support b) 315 scientific publications + 85 conference proceedings c) 29 Ph.D degrees awarded + postdoctoral training and M.Sc projects d) Four summer schools + three mini-symposia
NAC organisation Biomolecular NMR Spectroscopy RNA Molecular Biology Michael Petersen Stephen Douthwaite Birte Vester Synthetic Bioorganic Chemistry – DNA/LNA Chemistry Jesper Wengel Poul Nielsen Erik Bjerregaard Pedersen Stefan Vogel Patrick Hrdlicka (Univ. Idaho), Slava Vilichev (Massey Univ.), Anna Pasternak (PAS, Poznan) Rakesh N. Veedu (SDU), Andreas Stahl Madsen (KU), Kira Astakhova (SDU)
Grundforskning,anvendt forskning,strategisk forskning,innovation,produktudvikling... NAC (2001- ) i kontekst… Santaris Pharma A/S: - 50 ansatte 2014 - Fem lægemiddelkandidater i klinisk afprøvning – ”en antiMir” Exiqon A/S: - 70 ansatte 2014 - Fondsbørsen 2007 LNA-platform (NAC, KU, Santaris, Lundbeck, RiboTask; 77 mill kr) LNA Biotech spin-outs fra NAC: RiboTask, Pentabase, Tina-Company, Vogel-ApS… UNA
NACNucleic Acid Center NAC continues as a research unit supported by the University of Southern Denmark and external funding agencies - NAC instrument center! EVOLNA BioNEC Department of Physics, Chemistry and Pharmacy & Department of Biochemistry and Molecular Biology University of Southern Denmark
EVOLNA – Evolution of LNA-based aptamers UNA - Short yet highly structured and biostable aptamers
Professor Jesper Wengel (SDU) Nucleic acid chemistry and functional DNA nanostructures Lektor Stefan Vogel (SDU) Lipid chemistry, bioconjugates and nanoparticles Professor Knud J. Jensen (KU) Peptide and carbohydrate chemistry Professor Jørgen Kjems (AU) nano-biology
BioNEC projects… LNA architecture directs assembly of de novo designed proteins - new properties
Grundforskning,anvendt forskning,strategisk forskning,innovation,produktudvikling... NAC (2001- ) i kontekst… LNA-platform (NAC, KU, Santaris, Lundbeck, RiboTask; 77 mill kr) Nucleoside medicinal chemistry