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Is Blood Important to Life?. What is BLOOD?. http://www.youtube.com/watch?v=CRh_dAzXuoU. What is the functions of blood?. Transportation Regulation Protection. Transportation. Nutrients Waste Gases Hormones. Regulation. Fluid – Electrolyte balance Acid – Base balance
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What is BLOOD? • http://www.youtube.com/watch?v=CRh_dAzXuoU
What is the functions of blood? • Transportation • Regulation • Protection
Transportation • Nutrients • Waste • Gases • Hormones
Regulation • Fluid – Electrolyte balance • Acid – Base balance • Body temperature
Protection • Against pathogens • Against blood loss
Characteristics of Blood • pH 7.35 – 7.45 • 4 – 6 Liters • Mostly water • Oxygenated blood (arterial) - bright RED • De-oxygenated blood (venous) – dark RED (appears bluish in color) • Viscosity – 3 – 5x thicker than H2O
What carries blood? • Arteries – away from heart (oxygenated) • Veins – Toward the heart (deoxygenated) • Capillaries – connects the two types & in smaller areas
Components of Blood • Plasma • Red Blood Cells • White Blood Cells • Platelets
PLASMA • Liquid part of blood • About 90% water • Transports many types of substances • Glucose • Amino acids • Minerals • Waste products
Albumin • Most abundant plasma protein • Made by the liver • Contributes to Colloid Osmotic Pressure
Red Blood Cells • Erythrocytes - Erythro means red • Do not have a nucleus • 4.5 – 6 million in 1 microliter of blood • Men have more • Hemoglobin • Heme (Hb)– Iron (Fe) • Each molecule can carry 4 molecules of oxygen • Normal 12 – 18 in 100 ml blood • Made in Red Bone Marrow • Pelvis • Sternum
Hypoxia – lacking oxygen • Erythropoietin • B12 & folic acid are necessary for RBC production
Life Span • RBC’s live around 120 days • Removed from circulation by the liver, red bone marrow, & spleen • Eaten by macrophages & the iron is returned to circulation • The iron is sent to the red bone marrow for new RBC’s • Liver stores excess Iron • Heme part is not recycled & is converted to bilirubin by the liver • Bilirubin in bile during digestion & then excreted by the colon in fesces
White Blood Cells • Neutrophils • Eosinophils • Basophils
Platelets • Thromobocytes • Fragments or pieces of cells • Live 5 – 9 days • Normal is 150,000 – 300,000 /microliter • Thrombocytopenia
Vascular Spasm • Smooth muscles in the walls contract to close the hole • Platelet Plug • When Capillaries rupture& platelets stick together • Chemical Clotting • Begin within 15 – 120 seconds • Factor VIII; Vitamin K; Fibrin; Prothrombin
Blood Types • Genetic • A – has A antigen on RBC • B – has B antigen on RBC • AB – has both A & B antigens • O – has neither A nor B antigens • Rh Factor: Positive/Negative • Rh antigen is present – Positive • Rh antigen is not present - Negative