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Projects

Projects. Signal transduction pathways for A utosomal- d ominant p olycystic k idney d isease in mouse. (with Dr. Hung Li , Inst. Mol. Biolog , AS ) Inferring gene networks for HBx induced liver cancer using genomics data (with Dr. Cathy Yuh, NHRI )

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Projects

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  1. Projects • Signal transduction pathways for Autosomal-dominant polycystic kidney disease in mouse. (with Dr. Hung Li, Inst. Mol. Biolog, AS) • Inferring gene networks for HBx induced liver cancer using genomics data (with Dr. Cathy Yuh, NHRI ) • Predicting molecular mechanism for Obesity. (with Prof. Zucker, Univ Paris-6 and INSERM, France) • Epigenetics in yeast via ChIP-chip and microarray data. (with Dr. Cheng-Fu Kao, Inst. Cellular & Organ. Biology, AS)

  2. Introduction of ADPKD Autosomal-dominant polycystic kidney disease inherited disorder: 是造成腎衰竭(ESRD)的第三大原因 85% of ADPKD patients are due to pkd1gene mutation or pkd2 gene mutation Liver cysts High blood pressure Kidney stones Renal failure dialysis or a renal transplant

  3. Pkd1 gene mutate Pkd1L3/L3 Genotype of mouse Transgenic mice Time course data Phenotype (size of kidney) Mouse cDNA microarray

  4. Genomic Analysis of HBx induced HCC mouse model Chio-Hwa Yuh, PhD Associate Investigator Division of Molecular and Genomic Medicine National Health Research Institute

  5. Epigenetic regulation in transcription Cheng-Fu Kao (高承福) Inst. of Cellular & Organismic Biology Academia Sinica

  6. Epigenetics: • The word “epigenetic” literally means “outside conventional genetics.”

  7. Acknowledgement Dr. Hung Li and Wen-Cheng Chen, Inst. Molecular Biol., A.S. Drs. Cheng-Fu Kao ans Yi-Cheng Lo, Inst. Cellular & Organismic Biology, A.S. Dr. Chiou-Hua Yuh, Molecular & Genome Medicine, NHRI Dr. Jean-Daniel Zucker andRamzi Temanni, INSERM, Paris VI & Paris XIII Univ, France Dr. Ting-Fang Wang and Da-Yow Huang, Inst. of Biological Chemistry, A.S. Cheng-Long Chuang, Chin-Yuan Guo, Dr. Shi-Fong Guo, Dr. Shang-Kai Tai, Chia-Chang Wang, Yu-Bin Wang Inst. of Statistical Science, A.S.

  8. Other Collaborators • Prof. Kunio Shimizu and Dr. Shogo Kato, Dept. of Math., Keio Univ., Japan • Prof. Shinto Eguchi, Inst. of Stat. Math, Japan • Prof. Richard A. Johnson, Univ-Wisconsin- Madison, USA • Dr. Shurong Zeng, Dept. of Statistics, North-eastern Normal Univ., China

  9. Summer Research Students and visitors • Prof. Feng-Sheng Wang, Chem. Engr., National Chung-Cheng Univ. • Dr. Hong Yin, Ranmi Univ., China • Mary Pacold PhD student in Bioinformatics, UCSD, USA • Ramzi Temanni, PhD student in Bioinformatics, Paris XIII Univ.-Paris, France

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