Tau Phosphorylation
Tau protein is produced by alternative mRNA splicing of a single gene MAPT. Human MAPT is located at the chromosomal locus 17q21 and contains 16 exons, and alternative splicing of exons 2, 3, and 10 yields six isoforms. The structure of tau protein is divided into four regions: an acidic N-terminal region, a proline-rich region, a microtubule-binding domain (MBD) that is responsible for tau binding to microtubules and a C-terminal region.
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