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GosNIIOKhT and its Pharmaceutical Program

GosNIIOKhT and its Pharmaceutical Program. Dr. Anton Utkin, Head of Laboratory GosNIIOKhT Tel: 7-095-2738637 Shosse Entuziastov, 23 Fax:7-095-2732217 Moscow, 111024 . National Research Center of Russian Federation.

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GosNIIOKhT and its Pharmaceutical Program

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  1. GosNIIOKhTand its Pharmaceutical Program Dr. Anton Utkin, Head of Laboratory GosNIIOKhT Tel: 7-095-2738637 Shosse Entuziastov, 23 Fax:7-095-2732217 Moscow, 111024

  2. National Research Center of Russian Federation • National Scientific Research Institute of Organic Chemistry and Technology • Founded in 1915 • Had 6 branches • R&D in basic organic synthesis • 1994 – National Research Center • 1997 – Leading organization in Chem Demil

  3. Major Developments • Ethylene oxide • Acrylonitrile, caprolactam • Adiponitrile, polychlorovynil resins • Production of phenol and acetone by cumene method • Hydrocyanic acid from methane and ammonia • Cyanogene chloride, cyanurchloride, pesticides of thyazine, methylmetacrylate, organic glass • Propylene oxide, antifreeze, complexones, rubber, stabilizers

  4. Major Developments (continue) • Pesticides of different types • Surface-active compounds, feed additives • Organophosphorus pesticides • Extractants and flotation agents • Fluoroorganic lubrications (for space and underwater work) • Fluoro monomers and polymers, highly pure polytetrafluoroethylene (radio-chemical method) • Vitrification of radioactive waste

  5. R&D Capabilities • Organic and physical chemistry • Bioorganic chemistry, chemistry of natural and biologically active compounds • Chemical engineering • Toxicology, pharmacology, biochemistry • Test facility • Central Analytical Laboratory • 144 Ph.D., 31 Doctor of Science, 4 Scientific Boards

  6. Foreign Clients • Bechtel • Battelle Memorial Institute • Parsons • Westinghouse • PNNL • Edgewood Research Center

  7. Major Directions Today • Conversion technologies • Destruction of chemical weapons and other hazardous materials • Drug development and production • Environmental safety • Structure-property study of biologically active compounds

  8. Pharmaceutical Program • Started in 1987 • Substances production • Final form production • Substances development • Forms development • Analytical support • New generations of medicines

  9. Production of Drugs • 13 Licenses (substances and final forms) • Tablet form • Healing composition based on lanthanum (Impran, Langlik) • Peptide drugs (Oxitacine, Bucereline) • Low fraction DNA from sturgeon milt • Toxicological tests

  10. Development • Analgesics (Bupronorphine) • Peptides • Natural medicines (ISTC #870) • Radioprotectors (ISTC #1032) • Nootropes • Forms development

  11. Prospects • Central Analytical Laboratory • Ampoule production line • GLP, GMP and QA/QC • Building #21 • Combinatorial chemistry and screening

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