1 / 11

Lab #6 Eutectic Mixture Preparation & Control

Lab #6 Eutectic Mixture Preparation & Control. Presentation to students of health college March 22, 2010. by: TA/ Mohammad Al-Mermesh, BSc., PGC,. Eutectic mixtures:. They are powders when mixed together, the physicochemical characteristics

signa
Download Presentation

Lab #6 Eutectic Mixture Preparation & Control

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lab#6Eutectic Mixture Preparation & Control Presentation tostudents of health college March 22, 2010 by: TA/ Mohammad Al-Mermesh, BSc., PGC,

  2. Eutectic mixtures: They are powders when mixed together, the physicochemical characteristics will be changed, such as formation of paste, clean liquid, lowering of the melting point, formation of salt and water. • How to solve EUTECTIC MIXTURE FORMATION PROBLEM? By adding substances have the following characteristics: • Very fine powder • Inert • Has high melting point

  3. Example: Rx Calculations: X 0.065 x12 Aminopyrine 36 gr. Acetyl salicylic acid 24 gr. Caffeine citrate 6gr. Phenobarbital 6 gr. 28.1 gm 18.72 gm 4.68 gm 4.68 gm - Pulv.Mitte.Fiat.xii packs

  4. Procedure (direct): • The problem: • formation of eutectic mixture due to increase moisture content by: • Aminopyrine (base) + Acetyl salicylic acid Salt+ H2O • Caffeine citrate + other powders increase moisture content (H2O) • The solution: • Mix ASA with half it’s weight of magnesium oxide • Mix the aminopyrine with half it’s weight of dried Starch • Add 3 grains of caffeine & phenobarbital then mix well by sifting Conclusion: • The powder compound is well-formed, dry and very fine powder • It is well controlled by the addition of: • Starch, to adsorb the moisture • Magnesium oxide to neutralize the acidity of ASA, so prevent salt & water formation

  5. Powders with small quantity of drugs (un-measurable quantities) : Hyoscine hydrobromide powder 300mcg/pack Rx Calculations X 5 1.5 mg 600 mg Hyoscine hydrobromide 300 mcg Lactose Qs. 120 mg 1 PACK =120 mg (the minimum weight for each pack) Mitte.Fiat.iv packs (prepare 4 packs) Sig: 1 pack to be given 30 min. before Journey. Place it directly at the back of the tongue.

  6. Procedure: The minimum weighable quantity (class B balance ) is 100 mg STEP1 Hoyscine hydrobromide 100 mg Lactose 900 mg 100 MG OF TRITURATE A Contains: 1. Mix by doubling-up and remove 100 mg (Triturate A) } Triturate A 100 mg of Hyoscine 1000 mg (Triturate A) X 100 mg (Triturate A) X = 10 mg of Hyoscine

  7. STEP2 Triturate A 100 mg Lactose 900 mg 100 MG OF TRITURATE B Contains: 10 mg of Hyoscine 1000 mg (TriturateB) X 150 mg (Triturate B) 2. Mix by doubling-up & remove 150 mg of Triturate B } Triturate B X = 1.5 mg of Hyoscine

  8. 3. Mix by doubling-up 120 mg portions (each pack) of final powder contain 300 mcg of Hyoscine hydrobromide 4.Weigh 120 mg aliquots and wrap in a powder paper STEP3: Triturate B 150 mg Lactose (5 x 120 mg – 150 mg ) = 450 mg 600 mg

  9. Uses: Anti-muscarinic drug used in the prevention of motion sickness Role of each: • Hyoscine hydrobromide: Active ingredient • Lactose: Diluent (inert substance) sTABILITY: 2 – 4 weeks

  10. LABELLING: Hyoscine hydrobromide powder 300 mcg / pack One pack to be given 30 minutes before Journey, Place it directly at the back of the tongue Keep in cool and dry place Name Expiry Date 2-4 WEEKS

  11. Thank You

More Related