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Membranes

Membranes. C483 Spring 2013. Trans fatty acids have physical properties like those of A) w-3 fatty acids. B) cis -fatty acids. C) unsaturated fatty acids. D) saturated fatty acids. Triacylglycerols are not found in cell membranes because they are A) amphipathic. B) not amphipathic.

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Membranes

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  1. Membranes C483 Spring 2013

  2. Trans fatty acids have physical properties like those of A) w-3 fatty acids. B) cis-fatty acids. C) unsaturated fatty acids. D) saturated fatty acids. Triacylglycerols are not found in cell membranes because they are A) amphipathic. B) not amphipathic. C) not abundant in cells. D) charged at biological pH. Glycerophospholipids have ________ heads and long ________ fatty acid tails. A) polar; polar B) polar; hydrophobic C) hydrophobic; polar D) hydrophobic; hydrophobic

  3. Which type of membrane protein might be dissociated from the membrane by changing the pH or the ionic strength? A) Integral membrane protein. B) Lipid-anchored membrane protein. C) Peripheral membrane protein. D) All of the above. Which can serve as an energy source for secondary active transport? A) Ion concentration gradient. B) Light. C) Electron transport. D) ATP → ADP

  4. Lipids and Membranes • There is a lot of important biochemistry of lipids. • We won’t cover it all! • The key points for this class have to do with their role in membranes and fat metabolism

  5. Overview • Read chapter 9, sections 1-4, 6, 8-10 • Section 9.11 is important in discussion • Major topics • Metabolism: fatty acids and triacylglyderieds • Membrane components: phosphoglycerides and steroids • Membrane structure and dynamics • Membrane function: transport

  6. Diversity

  7. Fatty Acids • Saturated • Unsaturated • Polyunsaturated • Cis and trans

  8. Triacylglyderides

  9. Phosphoglycerides • aka glycerophospholipids • Polar head, hydrophobic tail

  10. Diversity

  11. Phospholipases • Wide variety of phosphoglycerides • Processed by range of lipases • Snake venom

  12. Steroids • Structural similarity, functional diversity

  13. Membranes • Complex • Fluid • Dynamic • Compartment-alization • Communication • Gradients

  14. Lipid Bilayer

  15. Dynamic

  16. Fluid Mosaic • Glycoproteins, proteins • Affect of cholesterol

  17. Integral Membrane Proteins

  18. Lipid anchored membrane proteins

  19. Membrane Transport • No thermodynamics for now • Pores and channels • Selective permeability • Sets up gradients

  20. Types of Transport • Passive Transport—with concentration or charge gradient • Diffusion across membrane • Facilitated diffusion • Active Transport—goes against concentration or charge gradient • Requires energy input • Always facilitated

  21. Facilitated Transport

  22. Types of Transport • Both passive and active transport can be • Uniport • Symport • Antiport

  23. Primary and Secondary Transport

  24. Answers • D • B • B • C • A

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