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UK Bioinformatics Forum: Successful Strategies in Bioinformatics Business. “Strategic Advantages for Development and Commercialisation of a Proprietary Bioinformatics Database Platform in the Asia Pacific Region” ” DTI Conference Centre, London March 8 th 2005 By: Dr. Arif Anwar
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UK Bioinformatics Forum: Successful Strategies in Bioinformatics Business
“Strategic Advantages for Development and Commercialisation of a Proprietary Bioinformatics Database Platform in the Asia Pacific Region”” DTI Conference Centre, London March 8th 2005 By: Dr. Arif Anwar Vice President, Synamatix
Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities
Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities
Core Competencies with Asia Pacific Rim Forum Science Innovation Summit 2003
Projected Core Competencies with Asia Pacific Rim Forum Science Innovation Summit 2003
Malaysia as a case study…bioinformatics business • Stringent IP enforcement and protection • Attractive government incentives and support • Low start-up and “burn rate” costs • Excellent corporate and physical infrastructure • Skilled, yet cost effective labour force • Compelling location for Bio-business • Via realising funding opportunities • Establishing new companies • Off-shoring development or partnerships/collaborations
Annual Budget 3-year Budget 5-year Budget Pacific Rim Forum Science Innovation Summit 2003 Increasing government investment VISION 2020 The Malaysian Government has recently increased its spending budget to USD$7.9 Billion to develop the Biotechnology sector up to 2010
Synamatix: Success and Support go hand in hand Public and Private Sector Funding IT Infrastructure, Incentives and Grant Schemes *Global Strategic Partnerships *Diversification & Market Penetration
Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities
Leveraging strategic regional advantages • Cost • Environment • Cutting edge - High value IP - SynaBASE™ - universal • Very High potential ROI and IRR • Achieved significant development and commercialisation initiation using seed funding • Prudent financial management • Tracked for early profitability • High investor return
A proprietary database platform technology Data repository External Packages Internal software External development Internal development
Current and future Applications Comparative Genomics Chip design Personalised Medicine and Genomics Sequence Mining Mapping Motifs Proteomics Annotation Clustering & Assembly Phylogenetics
Patterns and structures • Finds, Stores, Relates & Structures • PATTERNS, • not FLAT FILES • No rules or training sets
1. Patterns and structures 2. Significance & Frequency SynaBASE automatically learns and maintains the significance and entropy of patterns and data
Relying on frequency alone is inadequate… The elephant and the giraffe walked up the mountain A graph showing Frequency of “string (word)” patterns in a sentence does not reflect meaning The elephant and the giraffe walked up the mountain A graph showing Probabilities of predicting Precessor and Successor Characters/events (string Significance) reflecting meaning
Patterns and structures • SIGNIFICANCE and Frequency • 3. Scale and 4. Speed • Unique method for structuring data leads to • Ultra-high-throughput applications becoming routinely accessible
10 Genome 10 9 Genome 9 8 Genome 8 7 Genome 7 Size of pattern database 6 Genome 6 5 Genome 5 4 Genome 4 3 Genome 3 2 Genome 2 1 Genome 1 2 4 6 8 10 Number of Human genome copies
10 9 8 Size of pattern database 7 6 5 4 Genome 10 Genome 9 Genome 8 Genome 7 3 Genome 6 Genome 5 Genome 4 2 Genome 3 Genome 2 1 Genome 1 2 4 6 8 10 Number of genomes
Analysis speed scales at logn base 2 Speed milliseconds 900 800 Conventional 700 600 SynaBASE 500 400 300 200 100 Size of database giga bp 1 10 100 1000
All Prokaryotes All genomes!! All variants!! All Multiples…. All Eukaryotes Human Virus Mouse Ultra-high-throughput analysis 1stPersonalised medicine data mining capability All Plants Sequence data
Patterns and structures • SIGNIFICANCE and Entropy • Speed and 4. Scale • 5. Future proof • A non brute force investment, • hardware independence leads to novel applications • or challenging research projects
Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities
Technology Business Comparative genomics Personal genome data Personalised medicine Ultra-high-speed genomic analysis Co-research and publication OEM and embedding Distributors – multi-directional Co-technology leverage/development MGRC research and distribution Core competence sharing
Summary • Asia represents a compelling dual opportunity • Regional advantages of establishing or investing in Bioinformatics operations • Cost • Incentives • Market opportunity • Synamatix case study • Innovative, seminal bio-database platform • Offering strategic advantages of Asia based operations • Low burn rate • High ROI • High IRR